Morphogenesis and Compartmentalization of the Intestinal Crypt

The adult mammalian intestine is composed of two connected structures, the absorptive villi and the crypts, which house progenitor cells. Mouse crypts develop postnatally and are the architectural unit of the stem cell niche, yet the pathways that drive their formation are not known. Here, we combin...

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Veröffentlicht in:	Developmental cell 2018-04, Vol.45 (2), p.183-197.e5
Hauptverfasser:	Sumigray, Kaelyn D., Terwilliger, Michael, Lechler, Terry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apical constriction Cell Compartmentation - physiology Cell Differentiation Cell Lineage crypt Female hinge Integrins - genetics Integrins - metabolism intestine Intestines - cytology Intestines - physiology Male Mice Mice, Knockout morphogenesis Morphogenesis - physiology Myosin Type II - genetics Myosin Type II - metabolism Neuropeptides - physiology niche patterning Rac1 rac1 GTP-Binding Protein - physiology Stem Cell Niche - physiology Stem Cells - cytology Stem Cells - physiology Transcriptome villi
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