Mapping macrophage polarization over the myocardial infarction time continuum

In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and scar formation. We hypothesized that macrophages undergo polarization state changes over the MI time course and assessed macrophage polarization transcriptomic signatures over the first week of MI. C57BL/6 J mal...

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Veröffentlicht in:	Basic research in cardiology 2018-07, Vol.113 (4), p.26-18, Article 26
Hauptverfasser:	Mouton, Alan J., DeLeon-Pennell, Kristine Y., Rivera Gonzalez, Osvaldo J., Flynn, Elizabeth R., Freeman, Tom C., Saucerman, Jeffrey J., Garrett, Michael R., Ma, Yonggang, Harmancey, Romain, Lindsey, Merry L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiology Cell Plasticity - genetics Cell Proliferation Cells, Cultured Collagen (type I) Coronary artery Disease Models, Animal Energy Metabolism Extracellular matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - pathology Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Flow Cytometry Gene expression Gene Expression Profiling Gene sequencing Genes Genotype Heart Heart attacks Heart diseases Inflammation Inflammation Mediators - metabolism Macrophages Macrophages - metabolism Macrophages - pathology Male Medicine Medicine & Public Health Metabolism Mice, Inbred C57BL Mitochondria Monocytes Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium - metabolism Myocardium - pathology Original Contribution Oxidative phosphorylation Phagocytosis Phenotype Phosphorylation Polarization Ribonucleic acid RNA Rodents Time Factors Transcriptome Ventricular Function, Left - genetics Ventricular Remodeling - genetics
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