Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure
This study was performed to investigate whether genetic variation in the epithelial sodium channel (ENaC) is associated with 24-h urinary sodium excretion and blood pressure. A total of 3345 participants of the KoGES_Ansan and Ansung study were eligible for this study. Genomic DNA samples were isola...
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| Veröffentlicht in: | Nutrients 2018-05, Vol.10 (5), p.612 |
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| description | This study was performed to investigate whether genetic variation in the epithelial sodium channel (ENaC) is associated with 24-h urinary sodium excretion and blood pressure. A total of 3345 participants of the KoGES_Ansan and Ansung study were eligible for this study. Genomic DNA samples were isolated from peripheral blood and genotyped on the Affymetrix Genome-Wide Human SNP Array 5.0. Thirty-four single nucleotide polymorphisms (SNPs) were extracted for gene regions (
,
, and
) as additive components by using Plink. Twenty-four-hour sodium excretions were estimated from spot urine samples using the Tanaka formula. The general linear model (GLM) was applied to assess the association between SNPs and urinary sodium excretion or blood pressure. In the
gene, six SNPs (rs4073291, rs12934362, rs7404408, rs4494543, rs5735, and rs6497657) were significantly different in 24-h urinary sodium excretion according to gene variants. However, no difference was found in blood pressure among participants with gene variants of ENaC. Our finding indicated that 24-h urinary sodium excretions were different according to variants of the
gene in large samples. Further studies to replicate these findings are warranted. |
| doi_str_mv | 10.3390/nu10050612 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5986492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2039295497</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-4a92b4a1802f3d4ae18e443c247955ce7960eb690f75c1fa6c580561ee41f853</originalsourceid><addsrcrecordid>eNqFkVtLXDEUhUOxVLG-9AeUQF9EGM09Jy-CHcYLCC3U9jVkcvbpRM4k0-Scqv_ejI63vjQvO2R_e7GyF0KfKDnk3JCjOFJCJFGUvUM7jGg2UUrwrVf3bbRXyjVZH0204h_QNjNaaiPNDro5KSX54IaQIk4dPoMIQ_D4l8ubxxDxsAA8W4Va-uB6_CO1YVzi6cLFCP3DCL6pXfwzh-jy3RMwu_UZHjRcbPHXPqUWf89QypjhI3rfub7A3qbuoqvT2dX0fHL57exienI58YKbYSKcYXPhaENYx1vhgDYgBPdMVPvSgzaKwFwZ0mnpaeeUlw2RigII2jWS76LjR9nVOF9C6yEO2fV2lcOyGrXJBfu2E8PC_k5_rTSNEoZVgf2NQE5_RiiDXYbioe9dhDQWy1ijDNeEN_9HCTfMSGF0Rb_8g16nMce6iEpJxRtJ2Frw4JHyOZWSoXv2TYldh29fwq_w59c_fUafoub3Q7yqGw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2056385028</pqid></control><display><type>article</type><title>Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Yang, Yoon Jung ; Kim, Jihye ; Kwock, Chang Keun</creator><creatorcontrib>Yang, Yoon Jung ; Kim, Jihye ; Kwock, Chang Keun</creatorcontrib><description>This study was performed to investigate whether genetic variation in the epithelial sodium channel (ENaC) is associated with 24-h urinary sodium excretion and blood pressure. A total of 3345 participants of the KoGES_Ansan and Ansung study were eligible for this study. Genomic DNA samples were isolated from peripheral blood and genotyped on the Affymetrix Genome-Wide Human SNP Array 5.0. Thirty-four single nucleotide polymorphisms (SNPs) were extracted for gene regions (
,
, and
) as additive components by using Plink. Twenty-four-hour sodium excretions were estimated from spot urine samples using the Tanaka formula. The general linear model (GLM) was applied to assess the association between SNPs and urinary sodium excretion or blood pressure. In the
gene, six SNPs (rs4073291, rs12934362, rs7404408, rs4494543, rs5735, and rs6497657) were significantly different in 24-h urinary sodium excretion according to gene variants. However, no difference was found in blood pressure among participants with gene variants of ENaC. Our finding indicated that 24-h urinary sodium excretions were different according to variants of the
gene in large samples. Further studies to replicate these findings are warranted.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10050612</identifier><identifier>PMID: 29757959</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>blood ; Blood pressure ; Deoxyribonucleic acid ; DNA ; epithelium ; Excretion ; genes ; Genetic diversity ; genetic variation ; Genomes ; genotyping ; linear models ; Peripheral blood ; single nucleotide polymorphism arrays ; Single-nucleotide polymorphism ; Sodium ; Sodium channels ; Urine</subject><ispartof>Nutrients, 2018-05, Vol.10 (5), p.612</ispartof><rights>Copyright MDPI AG 2018</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-4a92b4a1802f3d4ae18e443c247955ce7960eb690f75c1fa6c580561ee41f853</citedby><cites>FETCH-LOGICAL-c439t-4a92b4a1802f3d4ae18e443c247955ce7960eb690f75c1fa6c580561ee41f853</cites><orcidid>0000-0001-9395-0854</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986492/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986492/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29757959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yoon Jung</creatorcontrib><creatorcontrib>Kim, Jihye</creatorcontrib><creatorcontrib>Kwock, Chang Keun</creatorcontrib><title>Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>This study was performed to investigate whether genetic variation in the epithelial sodium channel (ENaC) is associated with 24-h urinary sodium excretion and blood pressure. A total of 3345 participants of the KoGES_Ansan and Ansung study were eligible for this study. Genomic DNA samples were isolated from peripheral blood and genotyped on the Affymetrix Genome-Wide Human SNP Array 5.0. Thirty-four single nucleotide polymorphisms (SNPs) were extracted for gene regions (
,
, and
) as additive components by using Plink. Twenty-four-hour sodium excretions were estimated from spot urine samples using the Tanaka formula. The general linear model (GLM) was applied to assess the association between SNPs and urinary sodium excretion or blood pressure. In the
gene, six SNPs (rs4073291, rs12934362, rs7404408, rs4494543, rs5735, and rs6497657) were significantly different in 24-h urinary sodium excretion according to gene variants. However, no difference was found in blood pressure among participants with gene variants of ENaC. Our finding indicated that 24-h urinary sodium excretions were different according to variants of the
gene in large samples. Further studies to replicate these findings are warranted.</description><subject>blood</subject><subject>Blood pressure</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>epithelium</subject><subject>Excretion</subject><subject>genes</subject><subject>Genetic diversity</subject><subject>genetic variation</subject><subject>Genomes</subject><subject>genotyping</subject><subject>linear models</subject><subject>Peripheral blood</subject><subject>single nucleotide polymorphism arrays</subject><subject>Single-nucleotide polymorphism</subject><subject>Sodium</subject><subject>Sodium channels</subject><subject>Urine</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkVtLXDEUhUOxVLG-9AeUQF9EGM09Jy-CHcYLCC3U9jVkcvbpRM4k0-Scqv_ejI63vjQvO2R_e7GyF0KfKDnk3JCjOFJCJFGUvUM7jGg2UUrwrVf3bbRXyjVZH0204h_QNjNaaiPNDro5KSX54IaQIk4dPoMIQ_D4l8ubxxDxsAA8W4Va-uB6_CO1YVzi6cLFCP3DCL6pXfwzh-jy3RMwu_UZHjRcbPHXPqUWf89QypjhI3rfub7A3qbuoqvT2dX0fHL57exienI58YKbYSKcYXPhaENYx1vhgDYgBPdMVPvSgzaKwFwZ0mnpaeeUlw2RigII2jWS76LjR9nVOF9C6yEO2fV2lcOyGrXJBfu2E8PC_k5_rTSNEoZVgf2NQE5_RiiDXYbioe9dhDQWy1ijDNeEN_9HCTfMSGF0Rb_8g16nMce6iEpJxRtJ2Frw4JHyOZWSoXv2TYldh29fwq_w59c_fUafoub3Q7yqGw</recordid><startdate>20180514</startdate><enddate>20180514</enddate><creator>Yang, Yoon Jung</creator><creator>Kim, Jihye</creator><creator>Kwock, Chang Keun</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9395-0854</orcidid></search><sort><creationdate>20180514</creationdate><title>Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure</title><author>Yang, Yoon Jung ; Kim, Jihye ; Kwock, Chang Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-4a92b4a1802f3d4ae18e443c247955ce7960eb690f75c1fa6c580561ee41f853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>blood</topic><topic>Blood pressure</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>epithelium</topic><topic>Excretion</topic><topic>genes</topic><topic>Genetic diversity</topic><topic>genetic variation</topic><topic>Genomes</topic><topic>genotyping</topic><topic>linear models</topic><topic>Peripheral blood</topic><topic>single nucleotide polymorphism arrays</topic><topic>Single-nucleotide polymorphism</topic><topic>Sodium</topic><topic>Sodium channels</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yoon Jung</creatorcontrib><creatorcontrib>Kim, Jihye</creatorcontrib><creatorcontrib>Kwock, Chang Keun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yoon Jung</au><au>Kim, Jihye</au><au>Kwock, Chang Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2018-05-14</date><risdate>2018</risdate><volume>10</volume><issue>5</issue><spage>612</spage><pages>612-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>This study was performed to investigate whether genetic variation in the epithelial sodium channel (ENaC) is associated with 24-h urinary sodium excretion and blood pressure. A total of 3345 participants of the KoGES_Ansan and Ansung study were eligible for this study. Genomic DNA samples were isolated from peripheral blood and genotyped on the Affymetrix Genome-Wide Human SNP Array 5.0. Thirty-four single nucleotide polymorphisms (SNPs) were extracted for gene regions (
,
, and
) as additive components by using Plink. Twenty-four-hour sodium excretions were estimated from spot urine samples using the Tanaka formula. The general linear model (GLM) was applied to assess the association between SNPs and urinary sodium excretion or blood pressure. In the
gene, six SNPs (rs4073291, rs12934362, rs7404408, rs4494543, rs5735, and rs6497657) were significantly different in 24-h urinary sodium excretion according to gene variants. However, no difference was found in blood pressure among participants with gene variants of ENaC. Our finding indicated that 24-h urinary sodium excretions were different according to variants of the
gene in large samples. Further studies to replicate these findings are warranted.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29757959</pmid><doi>10.3390/nu10050612</doi><orcidid>https://orcid.org/0000-0001-9395-0854</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | blood Blood pressure Deoxyribonucleic acid DNA epithelium Excretion genes Genetic diversity genetic variation Genomes genotyping linear models Peripheral blood single nucleotide polymorphism arrays Single-nucleotide polymorphism Sodium Sodium channels Urine |
| title | Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure |
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