Loss of Chromatin-Remodeling Proteins and/or CDKN2A Associates With Metastasis of Pancreatic Neuroendocrine Tumors and Reduced Patient Survival Times

Despite prognostic grading and staging systems, it is a challenge to predict outcomes for patients with pancreatic neuroendocrine tumors (PanNETs). Sequencing studies of PanNETs have identified alterations in death domain-associated protein (DAXX) and alpha-thalassemia/mental retardation X-linked ch...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2018-06, Vol.154 (8), p.2060-2063.e8
Hauptverfasser:	Roy, Somak, LaFramboise, William A., Liu, Ta-Chiang, Cao, Dengfeng, Luvison, Alyssa, Miller, Caitlyn, Lyons, Maureen A., O’Sullivan, Roderick J., Zureikat, Amer H., Hogg, Melissa E., Tsung, Allan, Lee, Kenneth K., Bahary, Nathan, Brand, Randall E., Chennat, Jennifer S., Fasanella, Kenneth E., McGrath, Kevin, Nikiforova, Marina N., Papachristou, Georgios I., Slivka, Adam, Zeh, Herbert J., Singhi, Aatur D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Chromatin Assembly and Disassembly - genetics Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p18 - genetics Disease-Free Survival DNA Copy Number Variations Exome Sequencing Female Humans Kaplan-Meier Estimate Male Middle Aged Mutation Neuroendocrine Tumors - genetics Neuroendocrine Tumors - mortality Neuroendocrine Tumors - pathology Neuroendocrine Tumors - surgery Nuclear Proteins - genetics Pancreas Pancreatectomy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Prognosis Prognostic Factor Risk
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