Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease

Variants at the ABCB4 or MDR2 locus, which encodes a biliary transport protein, are associated with a spectrum of cholestatic liver diseases. Exacerbation of liver disease has been linked to increased hepatic levels of interleukin (IL) 17, yet the mechanisms of this increase are not understood. We s...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2018-06, Vol.154 (8), p.2178-2193
Hauptverfasser:	Tedesco, Dana, Thapa, Manoj, Chin, Chui Yoke, Ge, Yong, Gong, Minghao, Li, Jing, Gumber, Sanjeev, Speck, Patrick, Elrod, Elizabeth J., Burd, Eileen M., Kitchens, William H., Magliocca, Joseph F., Adams, Andrew B., Weiss, David S., Mohamadzadeh, Mansour, Grakoui, Arash
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals ATP Binding Cassette Transporter, Subfamily B - genetics ATP-Binding Cassette Sub-Family B Member 4 Bile Ducts - cytology Bile Ducts - immunology Bile Ducts - microbiology Cells, Cultured Cholangitis, Sclerosing - microbiology Cholangitis, Sclerosing - pathology Cholangitis, Sclerosing - surgery Cholestasis - immunology Cholestasis - microbiology Cholestasis - pathology Cholestasis - surgery Disease Models, Animal End Stage Liver Disease - microbiology End Stage Liver Disease - pathology End Stage Liver Disease - surgery Female Gastrointestinal Microbiome Hepatitis C, Chronic - pathology Hepatitis C, Chronic - surgery Hepatitis C, Chronic - virology Humans Immune Response Interleukin-17 - antagonists & inhibitors Interleukin-17 - blood Interleukin-17 - immunology Interleukin-17 - metabolism Intestinal Microbiota Intraepithelial Lymphocytes - metabolism Lactobacillus gasseri - immunology Liver - cytology Liver - immunology Liver - microbiology Liver - pathology Liver Cirrhosis - immunology Liver Cirrhosis - microbiology Liver Cirrhosis - pathology Liver Cirrhosis - surgery Liver Disease Pathogenesis Liver Transplantation Male Mice Mice, Knockout Middle Aged PSC Receptors, Antigen, T-Cell, gamma-delta - antagonists & inhibitors Receptors, Antigen, T-Cell, gamma-delta - metabolism Young Adult
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