Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/β-catenin Pathway

Dysregulation of cholesterol is a common characteristic of human cancers including prostate cancer. This study observed an aberrant accumulation of cholesteryl ester in metastatic lesions using Raman spectroscopic analysis of lipid droplets in human prostate cancer patient tissues. Inhibition of cho...

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Veröffentlicht in:	Molecular cancer research 2018-06, Vol.16 (6), p.974-985
Hauptverfasser:	Lee, Hyeon Jeong, Li, Jie, Vickman, Renee E, Li, Junjie, Liu, Rui, Durkes, Abigail C, Elzey, Bennett D, Yue, Shuhua, Liu, Xiaoqi, Ratliff, Timothy L, Cheng, Ji-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Animal models Animals beta Catenin - metabolism Cancer Cell Line, Tumor Cholesterol Cholesterol Esters - metabolism Depletion Disease Models, Animal Esterification Esterification - genetics Fatty acids Gene expression Humans Inhibition Lesions Male Metastases Metastasis Mice Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Regulators Secretion Wnt protein β-Catenin
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