Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-analysis
Mesenchymal stem cells (MSC) have emerged as breakthrough treatments for myocardial infarction. However, the efficacy of MSC remains unclear. The aim of the study was to evaluate treatment effect of MSC in terms of mechanical, regenerative, and clinical outcomes for patients with myocardial infarcti...
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Veröffentlicht in: | International Journal of Stem Cells 2018-05, Vol.11 (1), p.1-12 |
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creator | Jeong, Hyunsuk Yim, Hyeon Woo Park, Hun-Jun Cho, Youngseung Hong, Hanter Kim, Na Jin Oh, Il-Hoan |
description | Mesenchymal stem cells (MSC) have emerged as breakthrough treatments for myocardial infarction. However, the efficacy of MSC remains unclear. The aim of the study was to evaluate treatment effect of MSC in terms of mechanical, regenerative, and clinical outcomes for patients with myocardial infarction (MI) using meta-analysis.
A systematic search and critical review of MEDLINE, EMBASE, and Cochrane database literature published from inception through December 2017 was performed. The inclusion criteria were randomized controlled trials, studies on patients with myocardial infarction, and studies compared with placebo as a control group.
A total of 950 patients from 14 randomized placebo controlled trials were included in the final meta-analysis. MSC treatment showed benefits for mechanical, regenerative, and clinical outcomes. In terms of mechanical outcomes, the LVEF of the MSC treatment group increased by 3.84% (95% CI: 2.32~5.35,
²=43) and the effect was maintained for up to 24 months. Regenerative outcomes were measured by scar mass and WMSI. Scar mass was reduced by -1.13 (95% CI: -1.80 to -0.46,
²=71) and WMSI was reduced by -0.05 (95% CI: -0.07 to -0.03,
²=45) at 6 months after MSC treatment. Mortality rate and incidence of re-hospitalization for HF in MSC group patients trended toward reduced incidence compared to the control group, although this was not statistically significant because of the low event rate.
The findings of this meta-analysis indicate that MSCs can be beneficial in improving heart function in the treatment of MI. However, the efficacy of MSCs must be further explored through large randomized controlled trials based on rigorous research design. |
doi_str_mv | 10.15283/ijsc17061 |
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A systematic search and critical review of MEDLINE, EMBASE, and Cochrane database literature published from inception through December 2017 was performed. The inclusion criteria were randomized controlled trials, studies on patients with myocardial infarction, and studies compared with placebo as a control group.
A total of 950 patients from 14 randomized placebo controlled trials were included in the final meta-analysis. MSC treatment showed benefits for mechanical, regenerative, and clinical outcomes. In terms of mechanical outcomes, the LVEF of the MSC treatment group increased by 3.84% (95% CI: 2.32~5.35,
²=43) and the effect was maintained for up to 24 months. Regenerative outcomes were measured by scar mass and WMSI. Scar mass was reduced by -1.13 (95% CI: -1.80 to -0.46,
²=71) and WMSI was reduced by -0.05 (95% CI: -0.07 to -0.03,
²=45) at 6 months after MSC treatment. Mortality rate and incidence of re-hospitalization for HF in MSC group patients trended toward reduced incidence compared to the control group, although this was not statistically significant because of the low event rate.
The findings of this meta-analysis indicate that MSCs can be beneficial in improving heart function in the treatment of MI. However, the efficacy of MSCs must be further explored through large randomized controlled trials based on rigorous research design.</description><identifier>ISSN: 2005-3606</identifier><identifier>ISSN: 2005-5447</identifier><identifier>EISSN: 2005-5447</identifier><identifier>DOI: 10.15283/ijsc17061</identifier><identifier>PMID: 29482311</identifier><language>eng</language><publisher>Korea (South): Korean Society for Stem Cell Research</publisher><subject>Review</subject><ispartof>International Journal of Stem Cells, 2018-05, Vol.11 (1), p.1-12</ispartof><rights>Copyright © 2018 by the Korean Society for Stem Cell Research 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-a0553e3303e2dc90387a3f75c69e0e7093c7a032e8c611a1705e9398bd2e64233</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984054/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984054/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29482311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Hyunsuk</creatorcontrib><creatorcontrib>Yim, Hyeon Woo</creatorcontrib><creatorcontrib>Park, Hun-Jun</creatorcontrib><creatorcontrib>Cho, Youngseung</creatorcontrib><creatorcontrib>Hong, Hanter</creatorcontrib><creatorcontrib>Kim, Na Jin</creatorcontrib><creatorcontrib>Oh, Il-Hoan</creatorcontrib><title>Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-analysis</title><title>International Journal of Stem Cells</title><addtitle>Int J Stem Cells</addtitle><description>Mesenchymal stem cells (MSC) have emerged as breakthrough treatments for myocardial infarction. However, the efficacy of MSC remains unclear. The aim of the study was to evaluate treatment effect of MSC in terms of mechanical, regenerative, and clinical outcomes for patients with myocardial infarction (MI) using meta-analysis.
A systematic search and critical review of MEDLINE, EMBASE, and Cochrane database literature published from inception through December 2017 was performed. The inclusion criteria were randomized controlled trials, studies on patients with myocardial infarction, and studies compared with placebo as a control group.
A total of 950 patients from 14 randomized placebo controlled trials were included in the final meta-analysis. MSC treatment showed benefits for mechanical, regenerative, and clinical outcomes. In terms of mechanical outcomes, the LVEF of the MSC treatment group increased by 3.84% (95% CI: 2.32~5.35,
²=43) and the effect was maintained for up to 24 months. Regenerative outcomes were measured by scar mass and WMSI. Scar mass was reduced by -1.13 (95% CI: -1.80 to -0.46,
²=71) and WMSI was reduced by -0.05 (95% CI: -0.07 to -0.03,
²=45) at 6 months after MSC treatment. Mortality rate and incidence of re-hospitalization for HF in MSC group patients trended toward reduced incidence compared to the control group, although this was not statistically significant because of the low event rate.
The findings of this meta-analysis indicate that MSCs can be beneficial in improving heart function in the treatment of MI. However, the efficacy of MSCs must be further explored through large randomized controlled trials based on rigorous research design.</description><subject>Review</subject><issn>2005-3606</issn><issn>2005-5447</issn><issn>2005-5447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVkdtKAzEQhoMoVtQbH0ByKcJqjrtZLwSpR1AErZcSpunURvZQk62yb2-wtejczMB8_HP4CTng7IRrYeSpf4-OFyznG2RHMKYzrVSxuaplzvIB2Y_xnaWQpSlzs00GolRGSM53yOsDRmzcrK-hos8d1nSIVUVHMwww7-m0DfQuuhnW3tFbhNDRSx8RIp7R5z4mHrrUecJPj18Umgl9wA4yaKDqo497ZGsKVcT9Vd4lL9dXo-Ftdv94cze8uM-cUqrLgGktUUomUUxcyaQpQE4L7fISGRaslK4AJgUal3MO6VqNZTpmPBGYKyHlLjlf6s4X4xonDpsuQGXnwdcQetuCt_87jZ_Zt_bT6tIoplUSOFoJhPZjgbGztY8ufQIabBfRpmcaY5TJRUKPl6gLbYwBp-sxnNkfS-zakgQf_l1sjf4aIL8BM_GHOA</recordid><startdate>20180530</startdate><enddate>20180530</enddate><creator>Jeong, Hyunsuk</creator><creator>Yim, Hyeon Woo</creator><creator>Park, Hun-Jun</creator><creator>Cho, Youngseung</creator><creator>Hong, Hanter</creator><creator>Kim, Na Jin</creator><creator>Oh, Il-Hoan</creator><general>Korean Society for Stem Cell Research</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180530</creationdate><title>Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-analysis</title><author>Jeong, Hyunsuk ; Yim, Hyeon Woo ; Park, Hun-Jun ; Cho, Youngseung ; Hong, Hanter ; Kim, Na Jin ; Oh, Il-Hoan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-a0553e3303e2dc90387a3f75c69e0e7093c7a032e8c611a1705e9398bd2e64233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Hyunsuk</creatorcontrib><creatorcontrib>Yim, Hyeon Woo</creatorcontrib><creatorcontrib>Park, Hun-Jun</creatorcontrib><creatorcontrib>Cho, Youngseung</creatorcontrib><creatorcontrib>Hong, Hanter</creatorcontrib><creatorcontrib>Kim, Na Jin</creatorcontrib><creatorcontrib>Oh, Il-Hoan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Stem Cells</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Hyunsuk</au><au>Yim, Hyeon Woo</au><au>Park, Hun-Jun</au><au>Cho, Youngseung</au><au>Hong, Hanter</au><au>Kim, Na Jin</au><au>Oh, Il-Hoan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-analysis</atitle><jtitle>International Journal of Stem Cells</jtitle><addtitle>Int J Stem Cells</addtitle><date>2018-05-30</date><risdate>2018</risdate><volume>11</volume><issue>1</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>2005-3606</issn><issn>2005-5447</issn><eissn>2005-5447</eissn><abstract>Mesenchymal stem cells (MSC) have emerged as breakthrough treatments for myocardial infarction. However, the efficacy of MSC remains unclear. The aim of the study was to evaluate treatment effect of MSC in terms of mechanical, regenerative, and clinical outcomes for patients with myocardial infarction (MI) using meta-analysis.
A systematic search and critical review of MEDLINE, EMBASE, and Cochrane database literature published from inception through December 2017 was performed. The inclusion criteria were randomized controlled trials, studies on patients with myocardial infarction, and studies compared with placebo as a control group.
A total of 950 patients from 14 randomized placebo controlled trials were included in the final meta-analysis. MSC treatment showed benefits for mechanical, regenerative, and clinical outcomes. In terms of mechanical outcomes, the LVEF of the MSC treatment group increased by 3.84% (95% CI: 2.32~5.35,
²=43) and the effect was maintained for up to 24 months. Regenerative outcomes were measured by scar mass and WMSI. Scar mass was reduced by -1.13 (95% CI: -1.80 to -0.46,
²=71) and WMSI was reduced by -0.05 (95% CI: -0.07 to -0.03,
²=45) at 6 months after MSC treatment. Mortality rate and incidence of re-hospitalization for HF in MSC group patients trended toward reduced incidence compared to the control group, although this was not statistically significant because of the low event rate.
The findings of this meta-analysis indicate that MSCs can be beneficial in improving heart function in the treatment of MI. However, the efficacy of MSCs must be further explored through large randomized controlled trials based on rigorous research design.</abstract><cop>Korea (South)</cop><pub>Korean Society for Stem Cell Research</pub><pmid>29482311</pmid><doi>10.15283/ijsc17061</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Review |
title | Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-analysis |
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