Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer

Wnt/β-catenin signaling is upregulated in triple-negative breast cancer (TNBC) compared to other breast cancer subtypes and normal tissues. Current Wnt/β-catenin inhibitors, such as niclosamide, target the pathway nonspecifically and exhibit poor pharmacokinetics/pharmacodynamics in vivo. Niclosamid...

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Veröffentlicht in:	International journal of molecular sciences 2018-05, Vol.19 (5), p.1524
Hauptverfasser:	Gangrade, Abhishek, Pathak, Vibha, Augelli-Szafran, Corinne E, Wei, Han-Xun, Oliver, Patsy, Suto, Mark, Buchsbaum, Donald J
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cytotoxicity Lymphocyte receptors
Online-Zugang:	Volltext
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