Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men

Tolcapone, a brain penetrant selective inhibitor of catechol-O-methyltransferase (COMT) devoid of psychostimulant properties, improves cognition and cortical information processing in rested volunteers, depending on the genotype of the functional Val158Met polymorphism of COMT. The impact of this co...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2018-06, Vol.43 (7), p.1599-1607
Hauptverfasser:	Valomon, Amandine, Holst, Sebastian C, Borrello, Alessandro, Weigend, Susanne, Müller, Thomas, Berger, Wolfgang, Sommerauer, Michael, Baumann, Christian R, Landolt, Hans-Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Attention Attention - drug effects Brain Catechol Catechol O-methyltransferase Catechol O-Methyltransferase - genetics Catechol O-Methyltransferase Inhibitors - pharmacology Cognition Dopamine Dopamine receptors Gene polymorphism Genetic diversity Genetic variance Genotype Genotype & phenotype Genotypes Heterozygotes Homeostasis Homozygotes Humans Information processing Male Methyltransferase Polymorphism, Single Nucleotide - genetics Prefrontal cortex Sleep and wakefulness Sleep deprivation Sleep Deprivation - genetics Sleep Deprivation - psychology Tolcapone Tolcapone - pharmacology Wakefulness Young Adult
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