The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic

Breast cancer (BC) is a heterogeneous disease with different molecular subtypes. The high conductance calcium-activated potassium channels (BK, Maxi-K channels) play an important role in the survival of some BC phenotypes, via membrane hyperpolarization and regulation of cell cycle. BK channels have...

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Veröffentlicht in:	Marine drugs 2018-05, Vol.16 (5), p.157
Hauptverfasser:	Goda, Amira A, Siddique, Abu Bakar, Mohyeldin, Mohamed, Ayoub, Nehad M, El Sayed, Khalid A
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Alkaloids Analogs Antagonists Aspartic acid Binding sites Breast cancer Calcium Calcium channels Calcium conductance Calcium-binding protein Cancer Cell cycle Cell proliferation Channels Chemical compounds Crystal structure Epidermal growth factor receptors ErbB-2 protein HER protein Hyperpolarization Indoles Intestine Invasiveness Molecular chains Pharmacology Phenotypes Potassium Potassium channels Potassium channels (calcium-gated) Potassium conductance Proliferation Proteins Receptor mechanisms Resistance Sensitizing Stat3 protein Terrestrial environments Tumor necrosis factor-α
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