Stomatin‐like protein 2 inhibits cisplatin‐induced apoptosis through MEK/ERK signaling and the mitochondrial apoptosis pathway in cervical cancer cells

Stomatin‐like protein 2 (STOML2 or SLP‐2) is an oncogenic anti‐apoptotic protein that is upregulated in several types of cancer, including cervical cancer. However, the mechanisms responsible for the SLP‐2 anti‐apoptotic function remain poorly understood. Here, we show that siRNA‐mediated SLP‐2 supp...

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Veröffentlicht in:	Cancer science 2018-05, Vol.109 (5), p.1357-1368
Hauptverfasser:	Hu, Guolin, Zhang, Jialu, Xu, Feifei, Deng, Huan, Zhang, Weiwei, Kang, Shijun, Liang, Weijiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Apoptosis Bax protein Blood Proteins - genetics Blood Proteins - metabolism Calcium (mitochondrial) Calcium - metabolism Caspase-3 Caspase-9 Cell adhesion & migration Cell Line, Tumor Cervical cancer Cervix Cisplatin Cisplatin - pharmacology Cytochrome c Cytosol Drug Resistance, Neoplasm Esophageal cancer Extracellular signal-regulated kinase Female Gene expression Gene Expression Regulation, Neoplastic - drug effects human cervical cancer Humans Infections MAP Kinase Signaling System MEK/ERK signaling Membrane potential Membrane Potential, Mitochondrial Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Mitochondria Mitochondria - genetics Mitochondria - metabolism mitochondrial apoptosis Original Phosphorylation Poly(ADP-ribose) polymerase Proteins Ribose Signal transduction siRNA SLP‐2 Software Up-Regulation Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism
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