Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb−/−Runx2+/− Murine Incisors

Adult Cebpb KO mice incisors present amelogenin-positive epithelium pearls, enamel and dentin allopathic hyperplasia, fewer Sox2 -positive cells in labial cervical loop epitheliums, and reduced Sox2 expression in enamel epithelial stem cells. Thus, Cebpb acts upstream of Sox2 to regulate stemness. I...

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Veröffentlicht in:	Scientific reports 2018-03, Vol.8 (1), p.5169-13, Article 5169
Hauptverfasser:	Saito, Kazuyuki, Takahashi, Katsu, Huang, Boyen, Asahara, Masakazu, Kiso, Honoka, Togo, Yumiko, Tsukamoto, Hiroko, Mishima, Sayaka, Nagata, Masaki, Iida, Machiko, Tokita, Yoshihito, Asai, Masato, Shimizu, Akira, Komori, Toshihisa, Harada, Hidemitsu, MacDougall, Mary, Sugai, Manabu, Bessho, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/51 13/89 14 38/77 42/41 631/136/532/489 631/80/86/2368 64/60 96/106 96/63 Ameloblasts Cbfa-1 protein Cementum Decorin Dental enamel Dental pulp Dentin Enamel Epithelium Humanities and Social Sciences Hyperplasia Incisors Mesenchyme multidisciplinary Pearls Polarity Rodents Science Science (multidisciplinary) Stem cell transplantation Stem cells Supernumerary Teeth
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