Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling

Chronic ethanol/alcohol (AL) dosing causes an elevation in homocysteine (Hcy) levels, which leads to the condition known as Hyperhomocysteinemia (HHcy). HHcy enhances oxidative stress and blood-brain-barrier (BBB) disruption through modulation of endoplasmic reticulum (ER) stress; in part by epigene...

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Veröffentlicht in:	Scientific reports 2018-03, Vol.8 (1), p.5158-16, Article 5158
Hauptverfasser:	George, Akash K., Behera, Jyotirmaya, Kelly, Kimberly E., Mondal, Nandan K., Richardson, Kennedy P., Tyagi, Neetu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2649/2150 631/443/376 64/60 692/617/375/364 82/80 96/95 Activating Transcription Factor 6 - metabolism Alcohol Analysis of Variance Animals Behavior, Animal Blood Pressure - physiology Blood-brain barrier Blood-Brain Barrier - physiopathology Capillary Permeability - physiology Cerebrovascular Circulation - physiology Cerebrovascular system Cognitive ability Cognitive Dysfunction - metabolism Deoxyribonucleic acid Dithiothreitol DNA Endoplasmic reticulum Endoplasmic Reticulum Stress - physiology Epigenesis, Genetic - physiology Epigenetics Ethanol Ethanol - administration & dosage Ethanol - adverse effects Ethanol - metabolism Exercise Test Exercise Therapy Homocysteine Homocysteine - metabolism Humanities and Social Sciences Hydrogen sulfide Hyperhomocysteinemia Hyperhomocysteinemia - chemically induced Hyperhomocysteinemia - therapy Male Membrane Proteins - metabolism Methylenetetrahydrofolate reductase Mice Mice, Inbred C57BL Models, Animal multidisciplinary Neurotoxicity Normal Distribution Oxidative stress Oxidative Stress - physiology Physical Conditioning, Animal - physiology Rodents Science Science (multidisciplinary) Transcription
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