TFAM is required for maturation of the fetal and adult intestinal epithelium

During development, the embryo transitions from a metabolism favoring glycolysis to a metabolism favoring mitochondrial respiration. How metabolic shifts regulate developmental processes, or how developmental processes regulate metabolic shifts, remains unclear. To test the requirement of mitochondr...

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Veröffentlicht in:	Developmental biology 2018-07, Vol.439 (2), p.92-101
Hauptverfasser:	Srivillibhuthur, Manasa, Warder, Bailey N., Toke, Natalie H., Shah, Pooja P., Feng, Qiang, Gao, Nan, Bonder, Edward M., Verzi, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques - methods Cell Self Renewal - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Fetus - metabolism Gene Expression Regulation - genetics Glycolysis - genetics Glycolysis - physiology High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism High Mobility Group Proteins - physiology Intestinal development Intestinal Mucosa - embryology Intestinal Mucosa - growth & development Intestinal Mucosa - metabolism Intestinal stem cells Mice Mitochondria Mitochondria - metabolism Mitochondrial Proteins - genetics Organogenesis - genetics Organogenesis - physiology Organoids - metabolism Stem Cells - metabolism TFAM Transcription Factors - metabolism
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