Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons

Potentially pathogenic alterations have been identified in individuals with autism spectrum disorders (ASDs) within a variety of key neurodevelopment genes. While this hints at a common ASD molecular etiology, gaps persist in our understanding of the neurodevelopmental mechanisms impacted by genetic...

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Veröffentlicht in:	Scientific reports 2018-05, Vol.8 (1), p.8423-15, Article 8423
Hauptverfasser:	DeRosa, Brooke A., El Hokayem, Jimmy, Artimovich, Elena, Garcia-Serje, Catherine, Phillips, Andre W., Van Booven, Derek, Nestor, Jonathan E., Wang, Lily, Cuccaro, Michael L., Vance, Jeffery M., Pericak-Vance, Margaret A., Cukier, Holly N., Nestor, Michael W., Dykxhoorn, Derek M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/1 14/19 14/63 38/77 38/91 631/136/532/2064/2158 631/378/1689/1373 9/30 9/74 Adolescent Autism Autistic Disorder - genetics Autistic Disorder - pathology Axon guidance Calcium Signaling Cell adhesion & migration Cell Differentiation Cell migration Cell Movement Child Child, Preschool Data processing Deoxyribonucleic acid DNA Etiology Gene expression Gene Expression Profiling Genetic diversity Genetic variance Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Male multidisciplinary Neurodevelopment Neurons - metabolism Neurons - pathology Pattern formation Pluripotency Ribonucleic acid RNA Science Stem cells Synapses - pathology Transcription Transcriptomes Transcriptomics Young Adult
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