Enantioselective fluorination of α-branched aldehydes and subsequent conversion to α-hydroxyacetals via stereospecific C-F bond cleavage

The highly enantioselective fluorination of α-branched aldehydes was achieved using newly developed chiral primary amine catalyst . Furthermore, the C-F bond cleavage of the resulting α-fluoroaldehydes proceeded smoothly under alcoholic alkaline conditions to yield the corresponding α-hydroxyacetals...

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Veröffentlicht in:	Chemical science (Cambridge) 2016-01, Vol.7 (2), p.1388-1392
Hauptverfasser:	Shibatomi, Kazutaka, Kitahara, Kazumasa, Okimi, Takuya, Abe, Yoshiyuki, Iwasa, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Amines Bonding Catalysts Chemistry Cleavage Conversion Fluorination
Online-Zugang:	Volltext
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