Downregulation of CPT2 promotes tumorigenesis and chemoresistance to cisplatin in hepatocellular carcinoma

Cancer cells often have characteristic changes in metabolism. Besides Warburg effect, abnormal lipid metabolism is also considered as one of the most typical metabolic symbols of cancer. Thus, understanding the mechanisms of cell metabolic reprogramming may provide a potential avenue for cancer trea...

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Veröffentlicht in:	OncoTargets and therapy 2018-01, Vol.11, p.3101-3110
Hauptverfasser:	Lin, Meihua, Lv, Duo, Zheng, Yunliang, Wu, Minglan, Xu, Chang, Zhang, Qiao, Wu, Lihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic agents Cancer Cancer cells Cancer metastasis Cancer therapies Carcinoma Carnitine Carnitine palmitoyltransferase Cell differentiation Chemoresistance Chemotherapy Cisplatin Committees Desaturase Development and progression DNA polymerases Down-regulation Drug resistance Enzymes Fatty acids Gene expression Health aspects Hepatocellular carcinoma Hepatoma Hospitals Laboratories Lipid metabolism Lipids Lipogenesis Liver cancer Medical prognosis Messenger RNA Metabolism Metabolites Metastases Metastasis Monounsaturated fatty acids Novels Original Research Oxidation-reduction reactions Palmitoyltransferase Polymerase chain reaction Protein biosynthesis Proteins Public health RNA RNA-directed DNA polymerase Stearoyl-CoA desaturase Therapeutic targets Transcription Tumorigenesis Tumors
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