HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect

Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dyi...

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Veröffentlicht in:	Cell death & disease 2018-05, Vol.9 (6), p.648-13, Article 648
Hauptverfasser:	He, Sijia, Cheng, Jin, Sun, Lianhui, Wang, Yiwei, Wang, Chuangui, Liu, Xinjian, Zhang, Zhengxiang, Zhao, Minghui, Luo, Yuntao, Tian, Ling, Li, Chuanyuan, Huang, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/51 14/1 14/105 14/19 14/63 82/80 96/95 Advanced glycosylation end products Antibodies Antigens, Neoplasm - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - radiation effects Cell Survival - radiation effects Chemotherapy Female Glycosylation HMGB1 protein HMGB1 Protein - metabolism Humans Immunology Life Sciences Male MAP Kinase Signaling System - radiation effects Middle Aged Mitogen-Activated Protein Kinases - metabolism Multivariate Analysis Neoplasms - metabolism Neoplasms - pathology Paracrine Communication - radiation effects Paracrine signalling Prognosis Protein Binding Radiation therapy Signal transduction Survival Analysis Tumor cells
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