A novel variant associated with HDL-C levels by modifying DAGLB expression levels: An annotation-based genome-wide association study

Although numbers of genome-wide association studies (GWAS) have been performed for serum lipid levels, limited heritability has been explained. Studies showed that combining data from GWAS and expression quantitative trait loci (eQTLs) signals can both enhance the discovery of trait-associated SNPs...

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Veröffentlicht in:	European journal of human genetics : EJHG 2018-06, Vol.26 (6), p.838-847
Hauptverfasser:	Zhou, Dan, Zhang, Dandan, Sun, Xiaohui, Li, Zhiqiang, Ni, Yaqin, Shan, Zhongyan, Li, Hong, Liu, Chengguo, Zhang, Shuai, Liu, Yi, Zheng, Ruizhi, Pan, Feixia, Zhu, Yimin, Shi, Yongyong, Lai, Maode
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Alleles Cholesterol Cholesterol, HDL - blood Cholesterol, HDL - genetics Diglycerides Female Gene Expression Regulation Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genotype Genotypes Haplotypes Heritability High density lipoprotein Humans Lipase Lipid metabolism Lipid Metabolism - genetics Lipids Lipoprotein lipase Lipoprotein Lipase - blood Lipoprotein Lipase - genetics Low density lipoprotein Male Molecular Sequence Annotation Phenotype Phenotypes Polymorphism, Single Nucleotide Quantitative trait loci Quantitative Trait Loci - genetics Single-nucleotide polymorphism
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