3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo

As a novel low-side-effect cancer therapy, photo-immunotherapy (PIT) is based on conjugating monoclonal antibody (mAb) with a near-infrared (NIR) phthalocyanine dye IRDye700DX (IR 700). IR700 is not only fluorescent to be used as an imaging agent, but also phototoxic. When illuminating with NIR ligh...

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Veröffentlicht in:	Journal of controlled release 2018-06, Vol.279, p.171-180
Hauptverfasser:	Tang, Qinggong, Nagaya, Tadanobu, Liu, Yi, Horng, Hannah, Lin, Jonathan, Sato, Kazuhide, Kobayashi, Hisataka, Chen, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - chemistry Carbocyanines - chemistry Carcinoma, Squamous Cell - therapy Cell Line, Tumor Coloring Agents - chemistry Enhanced permeability and retention effect Female Fluorescence Fluorescence laminar optical tomography (FLOT) Immunoconjugates - administration & dosage Immunoconjugates - chemistry Immunotherapy - methods Infrared Rays Mice Mice, Nude Microscopy, Fluorescence, Multiphoton - methods Organophosphorus Compounds - chemistry Photoimmunotherapy (PIT) Phototherapy - methods Tomography, Optical - methods Tomography, Optical Coherence - methods Two-photon microscopy (TPM)
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