First-Trimester Uterine Artery Pulsatility Index and Maternal Serum PAPP-A and PlGF in Prediction of Preeclampsia in Primigravida
Background Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and a...
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| Veröffentlicht in: | Journal of obstetrics and gynaecology of India 2018-06, Vol.68 (3), p.192-196 |
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| creator | Salem, Mostafa Abdo Ahmed Ammar, Islam Mohamed Magdi |
| description | Background
Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and application of prophylactic procedures.
Objective
The aim of this work is to evaluate the role of mean pulsatility index (PI) of the uterine arteries and maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) in early preeclampsia prediction in primigravida.
Patients and Methods
Three hundred primigravida attending the antenatal care clinic in Zagazig University Hospitals were included in the study. The mean PI of the uterine arteries was calculated. Maternal serum levels of PAPP-A and PIGF were analyzed by specific immunoassay.
Results
Three hundred women were included in the final analysis, of them 30 patients (10%) suffered from preeclampsia. There was a significant difference between preeclamptic and normal women as regards the mean PI of the uterine arteries and levels of PAPP-A and PIGF at 11–13 weeks. When combining the cutoff levels of the three methods, mean PI of the uterine arteries ≥1.69, PAPP-A assay |
| doi_str_mv | 10.1007/s13224-017-1012-5 |
| format | Article |
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Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and application of prophylactic procedures.
Objective
The aim of this work is to evaluate the role of mean pulsatility index (PI) of the uterine arteries and maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) in early preeclampsia prediction in primigravida.
Patients and Methods
Three hundred primigravida attending the antenatal care clinic in Zagazig University Hospitals were included in the study. The mean PI of the uterine arteries was calculated. Maternal serum levels of PAPP-A and PIGF were analyzed by specific immunoassay.
Results
Three hundred women were included in the final analysis, of them 30 patients (10%) suffered from preeclampsia. There was a significant difference between preeclamptic and normal women as regards the mean PI of the uterine arteries and levels of PAPP-A and PIGF at 11–13 weeks. When combining the cutoff levels of the three methods, mean PI of the uterine arteries ≥1.69, PAPP-A assay <0.96 multiple of median (MoM) and PlGF assay <0.91 MoM, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were 56.7, 99.3, 89.5, 95.4 and 67%, respectively.
Conclusion
The combined measurement of maternal serum PAPP-A and PlGF concentrations and mean PI of the uterine arteries at 11–13 weeks of pregnancy may help to predict preeclampsia in primigravida when other parameters of preeclampsia prediction are normal. However, we need more studies on larger and variable populations to evaluate the use of those combined methods in preeclampsia prediction.</description><identifier>ISSN: 0971-9202</identifier><identifier>EISSN: 0975-6434</identifier><identifier>DOI: 10.1007/s13224-017-1012-5</identifier><identifier>PMID: 29895998</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Gynecology ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Original ; Original Article</subject><ispartof>Journal of obstetrics and gynaecology of India, 2018-06, Vol.68 (3), p.192-196</ispartof><rights>Federation of Obstetric & Gynecological Societies of India 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-619ed8ae8da1fb51f75d34970889cef589e04764c118906cdba7594febc3dd9c3</citedby><cites>FETCH-LOGICAL-c442t-619ed8ae8da1fb51f75d34970889cef589e04764c118906cdba7594febc3dd9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972089/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972089/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29895998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salem, Mostafa Abdo Ahmed</creatorcontrib><creatorcontrib>Ammar, Islam Mohamed Magdi</creatorcontrib><title>First-Trimester Uterine Artery Pulsatility Index and Maternal Serum PAPP-A and PlGF in Prediction of Preeclampsia in Primigravida</title><title>Journal of obstetrics and gynaecology of India</title><addtitle>J Obstet Gynecol India</addtitle><addtitle>J Obstet Gynaecol India</addtitle><description>Background
Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and application of prophylactic procedures.
Objective
The aim of this work is to evaluate the role of mean pulsatility index (PI) of the uterine arteries and maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) in early preeclampsia prediction in primigravida.
Patients and Methods
Three hundred primigravida attending the antenatal care clinic in Zagazig University Hospitals were included in the study. The mean PI of the uterine arteries was calculated. Maternal serum levels of PAPP-A and PIGF were analyzed by specific immunoassay.
Results
Three hundred women were included in the final analysis, of them 30 patients (10%) suffered from preeclampsia. There was a significant difference between preeclamptic and normal women as regards the mean PI of the uterine arteries and levels of PAPP-A and PIGF at 11–13 weeks. When combining the cutoff levels of the three methods, mean PI of the uterine arteries ≥1.69, PAPP-A assay <0.96 multiple of median (MoM) and PlGF assay <0.91 MoM, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were 56.7, 99.3, 89.5, 95.4 and 67%, respectively.
Conclusion
The combined measurement of maternal serum PAPP-A and PlGF concentrations and mean PI of the uterine arteries at 11–13 weeks of pregnancy may help to predict preeclampsia in primigravida when other parameters of preeclampsia prediction are normal. However, we need more studies on larger and variable populations to evaluate the use of those combined methods in preeclampsia prediction.</description><subject>Gynecology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original</subject><subject>Original Article</subject><issn>0971-9202</issn><issn>0975-6434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv3CAQhVHVqkmT_IBeKo690AIGYy6VVlE2jZQqlpqcEQvjLZGNt2BH3WP_edk4jdpLLjDovXkz4kPoPaOfGKXqc2YV54JQpgijjBP5Ch1TrSSpRSVeP9aMaE75EXqX8z2lUlEu3qIjrhsttW6O0e91SHkitykMkCdI-K4cIQJepVLscTv32U6hD9MeX0UPv7CNHn-zRYy2x98hzQNuV21LVo9K21-ucYi4TeCDm8IY8dgdXuB6O-xysIsahrBN9iF4e4redLbPcPZ0n6C79cXt-VdyfXN5db66Jk4IPpGaafCNhcZb1m0k65T0ldCKNo120MlGAxWqFo6xRtPa-Y1VUosONq7yXrvqBH1ZcnfzZgDvIE7J9mZXVrFpb0YbzP9KDD_MdnwwUitOG10CPj4FpPHnXH7LDCE76HsbYZyz4VQKXfOaVsXKFqtLY84JuucxjJoDOrOgMwWdOaAzsvR8-He_546_rIqBL4ZcpLiFZO7H-UAhv5D6Bxf9prY</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Salem, Mostafa Abdo Ahmed</creator><creator>Ammar, Islam Mohamed Magdi</creator><general>Springer India</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>First-Trimester Uterine Artery Pulsatility Index and Maternal Serum PAPP-A and PlGF in Prediction of Preeclampsia in Primigravida</title><author>Salem, Mostafa Abdo Ahmed ; Ammar, Islam Mohamed Magdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-619ed8ae8da1fb51f75d34970889cef589e04764c118906cdba7594febc3dd9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Gynecology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salem, Mostafa Abdo Ahmed</creatorcontrib><creatorcontrib>Ammar, Islam Mohamed Magdi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of obstetrics and gynaecology of India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salem, Mostafa Abdo Ahmed</au><au>Ammar, Islam Mohamed Magdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First-Trimester Uterine Artery Pulsatility Index and Maternal Serum PAPP-A and PlGF in Prediction of Preeclampsia in Primigravida</atitle><jtitle>Journal of obstetrics and gynaecology of India</jtitle><stitle>J Obstet Gynecol India</stitle><addtitle>J Obstet Gynaecol India</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>68</volume><issue>3</issue><spage>192</spage><epage>196</epage><pages>192-196</pages><issn>0971-9202</issn><eissn>0975-6434</eissn><abstract>Background
Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and application of prophylactic procedures.
Objective
The aim of this work is to evaluate the role of mean pulsatility index (PI) of the uterine arteries and maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) in early preeclampsia prediction in primigravida.
Patients and Methods
Three hundred primigravida attending the antenatal care clinic in Zagazig University Hospitals were included in the study. The mean PI of the uterine arteries was calculated. Maternal serum levels of PAPP-A and PIGF were analyzed by specific immunoassay.
Results
Three hundred women were included in the final analysis, of them 30 patients (10%) suffered from preeclampsia. There was a significant difference between preeclamptic and normal women as regards the mean PI of the uterine arteries and levels of PAPP-A and PIGF at 11–13 weeks. When combining the cutoff levels of the three methods, mean PI of the uterine arteries ≥1.69, PAPP-A assay <0.96 multiple of median (MoM) and PlGF assay <0.91 MoM, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were 56.7, 99.3, 89.5, 95.4 and 67%, respectively.
Conclusion
The combined measurement of maternal serum PAPP-A and PlGF concentrations and mean PI of the uterine arteries at 11–13 weeks of pregnancy may help to predict preeclampsia in primigravida when other parameters of preeclampsia prediction are normal. However, we need more studies on larger and variable populations to evaluate the use of those combined methods in preeclampsia prediction.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>29895998</pmid><doi>10.1007/s13224-017-1012-5</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Gynecology Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Original Article |
| title | First-Trimester Uterine Artery Pulsatility Index and Maternal Serum PAPP-A and PlGF in Prediction of Preeclampsia in Primigravida |
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