Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases
Cardiovascular diseases (CVDs) have been recognized as first killer of human health. The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compound...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-14 |
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| creator | Wu, Huan-Lin Wang, Yonghua Zhang, Lu-Lu Lan, Tao-Hua Xu, Dan-Ping |
| description | Cardiovascular diseases (CVDs) have been recognized as first killer of human health. The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A “CVDs pathway” consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. All the data demonstrates that Wen-Dan Decoction has multiscale beneficial activity in CVDs treatment, which provides a new way for uncovering the molecular mechanisms and new evidence for clinical application of Wen-Dan Decoction in cardiovascular disease. |
| doi_str_mv | 10.1155/2018/5170854 |
| format | Article |
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The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A “CVDs pathway” consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. All the data demonstrates that Wen-Dan Decoction has multiscale beneficial activity in CVDs treatment, which provides a new way for uncovering the molecular mechanisms and new evidence for clinical application of Wen-Dan Decoction in cardiovascular disease.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/5170854</identifier><identifier>PMID: 29861771</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Chinese medicine ; Data processing ; Drugs ; Health aspects ; Heart failure ; Herbal medicine ; Medical treatment ; Medicine, Chinese ; Metabolism ; Molecular chains ; Molecular modelling ; Pharmacology ; Proteins ; Surgery ; Traditional Chinese medicine</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-14</ispartof><rights>Copyright © 2018 Tao-Hua Lan et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Tao-Hua Lan et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Tao-Hua Lan et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-1954da5cb3c9cf774bc0db5a2a1d023be139134a49e7d415d4552a86d842d51f3</citedby><cites>FETCH-LOGICAL-c499t-1954da5cb3c9cf774bc0db5a2a1d023be139134a49e7d415d4552a86d842d51f3</cites><orcidid>0000-0002-2889-4320 ; 0000-0001-8949-4446 ; 0000-0002-5393-9009 ; 0000-0002-3060-1072</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971304/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971304/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29861771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mannucci, Carmen</contributor><contributor>Carmen Mannucci</contributor><creatorcontrib>Wu, Huan-Lin</creatorcontrib><creatorcontrib>Wang, Yonghua</creatorcontrib><creatorcontrib>Zhang, Lu-Lu</creatorcontrib><creatorcontrib>Lan, Tao-Hua</creatorcontrib><creatorcontrib>Xu, Dan-Ping</creatorcontrib><title>Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Cardiovascular diseases (CVDs) have been recognized as first killer of human health. The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A “CVDs pathway” consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. All the data demonstrates that Wen-Dan Decoction has multiscale beneficial activity in CVDs treatment, which provides a new way for uncovering the molecular mechanisms and new evidence for clinical application of Wen-Dan Decoction in cardiovascular disease.</description><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Chinese medicine</subject><subject>Data processing</subject><subject>Drugs</subject><subject>Health aspects</subject><subject>Heart failure</subject><subject>Herbal medicine</subject><subject>Medical treatment</subject><subject>Medicine, Chinese</subject><subject>Metabolism</subject><subject>Molecular chains</subject><subject>Molecular modelling</subject><subject>Pharmacology</subject><subject>Proteins</subject><subject>Surgery</subject><subject>Traditional Chinese medicine</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUFv1DAQhSNERUvhxhlF4oJEQ23HjuNLpWqXUqQikCiCmzWxJ7uukrjYSdHy63HYZQucOHms-ea9sV-WPaPkNaVCnDJC61NBJakFf5AdUclpwVldP9zX8uth9jjGG0KYklI-yg6ZqisqJT3KfnzaxBH7mH9cQ-jB-M6vNvnSxYhmdH7IfZtfB7BuvkCXL9ZuwIj5e7TOpDL_gkOxhCFfovHbidaHNIIw9jiM8_wCgnX-DqKZOgizOELE-CQ7aKGL-HR3HmefL95cLy6Lqw9v3y3OrwrDlRoLqgS3IExTGmVaKXljiG0EMKCWsLJBWipacuAKpeVUWC4Eg7qyNWdW0LY8zs62urdT06M1aasAnb4Nroew0R6c_rszuLVe-TstlKQl4Ung5U4g-G8TxlH3LhrsOhjQT1EzkhYtVfJO6It_0Bs_hfRxvygqeCUrdk-toEPthtYnXzOL6vMqGVJOZJWoky1lgo8xYLtfmRI9R6_n6PUu-oQ___OZe_h31gl4tQVShBa-u_-Uw8RgC_d0QnlZlT8BJJjAxA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Wu, Huan-Lin</creator><creator>Wang, Yonghua</creator><creator>Zhang, Lu-Lu</creator><creator>Lan, Tao-Hua</creator><creator>Xu, Dan-Ping</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2889-4320</orcidid><orcidid>https://orcid.org/0000-0001-8949-4446</orcidid><orcidid>https://orcid.org/0000-0002-5393-9009</orcidid><orcidid>https://orcid.org/0000-0002-3060-1072</orcidid></search><sort><creationdate>20180101</creationdate><title>Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases</title><author>Wu, Huan-Lin ; 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The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A “CVDs pathway” consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. 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| subjects | Cardiovascular disease Cardiovascular diseases Care and treatment Chinese medicine Data processing Drugs Health aspects Heart failure Herbal medicine Medical treatment Medicine, Chinese Metabolism Molecular chains Molecular modelling Pharmacology Proteins Surgery Traditional Chinese medicine |
| title | Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases |
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