Nonhuman primate models of human viral infections

Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types a...

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Veröffentlicht in:	Nature reviews. Immunology 2018-06, Vol.18 (6), p.390-404
Hauptverfasser:	Estes, Jacob D., Wong, Scott W., Brenchley, Jason M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/63 631/1647/767/1972 631/250/255 Animal Experimentation - ethics Animal models Animal research models Animals Antiviral agents B cells Benchmarking Biomedical and Life Sciences Biomedicine Cercopithecidae - genetics Cercopithecidae - immunology Cercopithecidae - virology Disease Models, Animal DNA Virus Infections - genetics DNA Virus Infections - immunology DNA Virus Infections - virology Epidemics Health aspects Hominidae - genetics Hominidae - immunology Hominidae - virology Human behavior Humans Immune response Immune system Immunology Infection Infections Medical research Methods Models, Immunological Molecular chains Monkeys Phylogeny Physiological aspects Platyrrhini - genetics Platyrrhini - immunology Platyrrhini - virology Primates Primates - genetics Primates - immunology Primates - virology Reagents Review Article RNA Virus Infections - genetics RNA Virus Infections - immunology RNA Virus Infections - virology Species Specificity Vaccine efficacy Vaccines Viral infections Viral research Virus diseases Virus Diseases - genetics Virus Diseases - immunology Virus Diseases - virology Viruses
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