Nonhuman primate models of human viral infections
Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types a...
Gespeichert in:
Veröffentlicht in: | Nature reviews. Immunology 2018-06, Vol.18 (6), p.390-404 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 404 |
---|---|
container_issue | 6 |
container_start_page | 390 |
container_title | Nature reviews. Immunology |
container_volume | 18 |
creator | Estes, Jacob D. Wong, Scott W. Brenchley, Jason M. |
description | Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.
Nonhuman primates (NHPs) are increasingly used as models of human viral infections. Here, Estes and colleagues introduce different NHP models, summarize the similarities and differences between human and NHP immune systems and discuss important examples of human viruses that can be modelled in NHPs. |
doi_str_mv | 10.1038/s41577-018-0005-7 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5970954</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A572622357</galeid><sourcerecordid>A572622357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c696t-69fce3afec940ff9057eeeddc5feb5a6750edb1c907f6bf62b2b0c7a65ce02ed3</originalsourceid><addsrcrecordid>eNp9kl1rFTEQhhex2Fr9Ad7IgiB6sXXyffZGKEVtoSj4cR2y2ck5KbtJ3eyW9t-b062nXVHJRcLM804mk7coXhA4IsBW7xInQqkKyKoCAFGpR8UB4YpXRHHyeHdmbL94mtIFAJE586TYp7UQEog6KMjnGDZTb0J5OfjejFj2scUuldGVc_zKD6YrfXBoRx9DelbsOdMlfH63HxY_Pn74fnJanX_5dHZyfF5ZWcuxkrWzyExW1Rycq0EoRGxbKxw2wkglANuG2BqUk42TtKENWGWksAgUW3ZYvJ_rXk5Nj63FMOZG9G2bw42OxutlJviNXscrLWoFteC5wJu7AkP8OWEade-Txa4zAeOUNAUiVkwBkxl99Qd6Each5OdpRjjLw6Y1_R9FgWeMcgb31Np0qPPcYu7Obq_Wx0JRSSkTKlNHf6HyarH3NgZ0PscXgrcLQWZGvB7XZkpJn337umRfP2A3aLpxk2I33f7fEiQzaIeY0oBuN14CemsxPVtMZ4vprcX0VvPy4b_sFL89lQE6AymnwhqH-zH9u-ovGHfY0g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2044312430</pqid></control><display><type>article</type><title>Nonhuman primate models of human viral infections</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Estes, Jacob D. ; Wong, Scott W. ; Brenchley, Jason M.</creator><creatorcontrib>Estes, Jacob D. ; Wong, Scott W. ; Brenchley, Jason M.</creatorcontrib><description>Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.
Nonhuman primates (NHPs) are increasingly used as models of human viral infections. Here, Estes and colleagues introduce different NHP models, summarize the similarities and differences between human and NHP immune systems and discuss important examples of human viruses that can be modelled in NHPs.</description><identifier>ISSN: 1474-1733</identifier><identifier>ISSN: 1474-1741</identifier><identifier>EISSN: 1474-1741</identifier><identifier>DOI: 10.1038/s41577-018-0005-7</identifier><identifier>PMID: 29556017</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/31 ; 14/63 ; 631/1647/767/1972 ; 631/250/255 ; Animal Experimentation - ethics ; Animal models ; Animal research models ; Animals ; Antiviral agents ; B cells ; Benchmarking ; Biomedical and Life Sciences ; Biomedicine ; Cercopithecidae - genetics ; Cercopithecidae - immunology ; Cercopithecidae - virology ; Disease Models, Animal ; DNA Virus Infections - genetics ; DNA Virus Infections - immunology ; DNA Virus Infections - virology ; Epidemics ; Health aspects ; Hominidae - genetics ; Hominidae - immunology ; Hominidae - virology ; Human behavior ; Humans ; Immune response ; Immune system ; Immunology ; Infection ; Infections ; Medical research ; Methods ; Models, Immunological ; Molecular chains ; Monkeys ; Phylogeny ; Physiological aspects ; Platyrrhini - genetics ; Platyrrhini - immunology ; Platyrrhini - virology ; Primates ; Primates - genetics ; Primates - immunology ; Primates - virology ; Reagents ; Review Article ; RNA Virus Infections - genetics ; RNA Virus Infections - immunology ; RNA Virus Infections - virology ; Species Specificity ; Vaccine efficacy ; Vaccines ; Viral infections ; Viral research ; Virus diseases ; Virus Diseases - genetics ; Virus Diseases - immunology ; Virus Diseases - virology ; Viruses</subject><ispartof>Nature reviews. Immunology, 2018-06, Vol.18 (6), p.390-404</ispartof><rights>Macmillan Publishers Ltd., part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c696t-69fce3afec940ff9057eeeddc5feb5a6750edb1c907f6bf62b2b0c7a65ce02ed3</citedby><cites>FETCH-LOGICAL-c696t-69fce3afec940ff9057eeeddc5feb5a6750edb1c907f6bf62b2b0c7a65ce02ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29556017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Estes, Jacob D.</creatorcontrib><creatorcontrib>Wong, Scott W.</creatorcontrib><creatorcontrib>Brenchley, Jason M.</creatorcontrib><title>Nonhuman primate models of human viral infections</title><title>Nature reviews. Immunology</title><addtitle>Nat Rev Immunol</addtitle><addtitle>Nat Rev Immunol</addtitle><description>Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.
Nonhuman primates (NHPs) are increasingly used as models of human viral infections. Here, Estes and colleagues introduce different NHP models, summarize the similarities and differences between human and NHP immune systems and discuss important examples of human viruses that can be modelled in NHPs.</description><subject>13/31</subject><subject>14/63</subject><subject>631/1647/767/1972</subject><subject>631/250/255</subject><subject>Animal Experimentation - ethics</subject><subject>Animal models</subject><subject>Animal research models</subject><subject>Animals</subject><subject>Antiviral agents</subject><subject>B cells</subject><subject>Benchmarking</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cercopithecidae - genetics</subject><subject>Cercopithecidae - immunology</subject><subject>Cercopithecidae - virology</subject><subject>Disease Models, Animal</subject><subject>DNA Virus Infections - genetics</subject><subject>DNA Virus Infections - immunology</subject><subject>DNA Virus Infections - virology</subject><subject>Epidemics</subject><subject>Health aspects</subject><subject>Hominidae - genetics</subject><subject>Hominidae - immunology</subject><subject>Hominidae - virology</subject><subject>Human behavior</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infection</subject><subject>Infections</subject><subject>Medical research</subject><subject>Methods</subject><subject>Models, Immunological</subject><subject>Molecular chains</subject><subject>Monkeys</subject><subject>Phylogeny</subject><subject>Physiological aspects</subject><subject>Platyrrhini - genetics</subject><subject>Platyrrhini - immunology</subject><subject>Platyrrhini - virology</subject><subject>Primates</subject><subject>Primates - genetics</subject><subject>Primates - immunology</subject><subject>Primates - virology</subject><subject>Reagents</subject><subject>Review Article</subject><subject>RNA Virus Infections - genetics</subject><subject>RNA Virus Infections - immunology</subject><subject>RNA Virus Infections - virology</subject><subject>Species Specificity</subject><subject>Vaccine efficacy</subject><subject>Vaccines</subject><subject>Viral infections</subject><subject>Viral research</subject><subject>Virus diseases</subject><subject>Virus Diseases - genetics</subject><subject>Virus Diseases - immunology</subject><subject>Virus Diseases - virology</subject><subject>Viruses</subject><issn>1474-1733</issn><issn>1474-1741</issn><issn>1474-1741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl1rFTEQhhex2Fr9Ad7IgiB6sXXyffZGKEVtoSj4cR2y2ck5KbtJ3eyW9t-b062nXVHJRcLM804mk7coXhA4IsBW7xInQqkKyKoCAFGpR8UB4YpXRHHyeHdmbL94mtIFAJE586TYp7UQEog6KMjnGDZTb0J5OfjejFj2scUuldGVc_zKD6YrfXBoRx9DelbsOdMlfH63HxY_Pn74fnJanX_5dHZyfF5ZWcuxkrWzyExW1Rycq0EoRGxbKxw2wkglANuG2BqUk42TtKENWGWksAgUW3ZYvJ_rXk5Nj63FMOZG9G2bw42OxutlJviNXscrLWoFteC5wJu7AkP8OWEade-Txa4zAeOUNAUiVkwBkxl99Qd6Each5OdpRjjLw6Y1_R9FgWeMcgb31Np0qPPcYu7Obq_Wx0JRSSkTKlNHf6HyarH3NgZ0PscXgrcLQWZGvB7XZkpJn337umRfP2A3aLpxk2I33f7fEiQzaIeY0oBuN14CemsxPVtMZ4vprcX0VvPy4b_sFL89lQE6AymnwhqH-zH9u-ovGHfY0g</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Estes, Jacob D.</creator><creator>Wong, Scott W.</creator><creator>Brenchley, Jason M.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QR</scope><scope>7RV</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>Nonhuman primate models of human viral infections</title><author>Estes, Jacob D. ; Wong, Scott W. ; Brenchley, Jason M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c696t-69fce3afec940ff9057eeeddc5feb5a6750edb1c907f6bf62b2b0c7a65ce02ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/31</topic><topic>14/63</topic><topic>631/1647/767/1972</topic><topic>631/250/255</topic><topic>Animal Experimentation - ethics</topic><topic>Animal models</topic><topic>Animal research models</topic><topic>Animals</topic><topic>Antiviral agents</topic><topic>B cells</topic><topic>Benchmarking</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cercopithecidae - genetics</topic><topic>Cercopithecidae - immunology</topic><topic>Cercopithecidae - virology</topic><topic>Disease Models, Animal</topic><topic>DNA Virus Infections - genetics</topic><topic>DNA Virus Infections - immunology</topic><topic>DNA Virus Infections - virology</topic><topic>Epidemics</topic><topic>Health aspects</topic><topic>Hominidae - genetics</topic><topic>Hominidae - immunology</topic><topic>Hominidae - virology</topic><topic>Human behavior</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infection</topic><topic>Infections</topic><topic>Medical research</topic><topic>Methods</topic><topic>Models, Immunological</topic><topic>Molecular chains</topic><topic>Monkeys</topic><topic>Phylogeny</topic><topic>Physiological aspects</topic><topic>Platyrrhini - genetics</topic><topic>Platyrrhini - immunology</topic><topic>Platyrrhini - virology</topic><topic>Primates</topic><topic>Primates - genetics</topic><topic>Primates - immunology</topic><topic>Primates - virology</topic><topic>Reagents</topic><topic>Review Article</topic><topic>RNA Virus Infections - genetics</topic><topic>RNA Virus Infections - immunology</topic><topic>RNA Virus Infections - virology</topic><topic>Species Specificity</topic><topic>Vaccine efficacy</topic><topic>Vaccines</topic><topic>Viral infections</topic><topic>Viral research</topic><topic>Virus diseases</topic><topic>Virus Diseases - genetics</topic><topic>Virus Diseases - immunology</topic><topic>Virus Diseases - virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Estes, Jacob D.</creatorcontrib><creatorcontrib>Wong, Scott W.</creatorcontrib><creatorcontrib>Brenchley, Jason M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature reviews. Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Estes, Jacob D.</au><au>Wong, Scott W.</au><au>Brenchley, Jason M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonhuman primate models of human viral infections</atitle><jtitle>Nature reviews. Immunology</jtitle><stitle>Nat Rev Immunol</stitle><addtitle>Nat Rev Immunol</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>18</volume><issue>6</issue><spage>390</spage><epage>404</epage><pages>390-404</pages><issn>1474-1733</issn><issn>1474-1741</issn><eissn>1474-1741</eissn><abstract>Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.
Nonhuman primates (NHPs) are increasingly used as models of human viral infections. Here, Estes and colleagues introduce different NHP models, summarize the similarities and differences between human and NHP immune systems and discuss important examples of human viruses that can be modelled in NHPs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29556017</pmid><doi>10.1038/s41577-018-0005-7</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1474-1733 |
ispartof | Nature reviews. Immunology, 2018-06, Vol.18 (6), p.390-404 |
issn | 1474-1733 1474-1741 1474-1741 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5970954 |
source | MEDLINE; Nature; Alma/SFX Local Collection |
subjects | 13/31 14/63 631/1647/767/1972 631/250/255 Animal Experimentation - ethics Animal models Animal research models Animals Antiviral agents B cells Benchmarking Biomedical and Life Sciences Biomedicine Cercopithecidae - genetics Cercopithecidae - immunology Cercopithecidae - virology Disease Models, Animal DNA Virus Infections - genetics DNA Virus Infections - immunology DNA Virus Infections - virology Epidemics Health aspects Hominidae - genetics Hominidae - immunology Hominidae - virology Human behavior Humans Immune response Immune system Immunology Infection Infections Medical research Methods Models, Immunological Molecular chains Monkeys Phylogeny Physiological aspects Platyrrhini - genetics Platyrrhini - immunology Platyrrhini - virology Primates Primates - genetics Primates - immunology Primates - virology Reagents Review Article RNA Virus Infections - genetics RNA Virus Infections - immunology RNA Virus Infections - virology Species Specificity Vaccine efficacy Vaccines Viral infections Viral research Virus diseases Virus Diseases - genetics Virus Diseases - immunology Virus Diseases - virology Viruses |
title | Nonhuman primate models of human viral infections |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T15%3A28%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nonhuman%20primate%20models%20of%20human%20viral%20infections&rft.jtitle=Nature%20reviews.%20Immunology&rft.au=Estes,%20Jacob%20D.&rft.date=2018-06-01&rft.volume=18&rft.issue=6&rft.spage=390&rft.epage=404&rft.pages=390-404&rft.issn=1474-1733&rft.eissn=1474-1741&rft_id=info:doi/10.1038/s41577-018-0005-7&rft_dat=%3Cgale_pubme%3EA572622357%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2044312430&rft_id=info:pmid/29556017&rft_galeid=A572622357&rfr_iscdi=true |