Metabolically-derived lysine acylations and neighboring modifications tune BET bromodomain binding to histone H4

Recent proteomic studies discovered histone lysines are modified by acylations beyond acetylation. These acylations derive from acyl-CoA metabolites, potentially linking metabolism to transcription. Bromodomains bind lysine acylation on histones and other nuclear proteins to influence transcription....

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Veröffentlicht in:	Biochemistry (Easton) 2017-10, Vol.56 (41), p.5485-5495
Hauptverfasser:	Olp, Michael D., Zhu, Nan, Smith, Brian C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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