Advanced glycation end products-induced insulin resistance involves repression of skeletal muscle GLUT4 expression

Little is known about advanced glycation end products (AGEs) participation in glucose homeostasis, a process in which skeletal muscle glucose transporter GLUT4 ( Scl2a4 gene) plays a key role. This study investigated (1) the in vivo and in vitro effects of AGEs on Slc2a4 /GLUT4 expression in skeleta...

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Veröffentlicht in:	Scientific reports 2018-05, Vol.8 (1), p.8109-11, Article 8109
Hauptverfasser:	Pinto-Junior, Danilo C., Silva, Karolline S., Michalani, Maria L., Yonamine, Caio Y., Esteves, João V., Fabre, Nelly T., Thieme, Karina, Catanozi, Sérgio, Okamoto, Maristela M., Seraphim, Patricia M., Corrêa-Giannella, Maria L., Passarelli, Marisa, Machado, Ubiratan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 38/39 38/77 45 59 631/443/319 631/80/2023 82 82/29 82/80 96/95 Advanced glycosylation end products Age Albumin Diabetes mellitus Endoplasmic reticulum Glucose Glucose transporter Glycosylation Homeostasis Humanities and Social Sciences IKK protein Inflammation Insulin Insulin resistance mRNA multidisciplinary Muscles Musculoskeletal system NF-κB protein Proteins RelA protein Science Science (multidisciplinary) Skeletal muscle
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