Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control Excitability

RATIONALE:In cardiomyocytes, NaV1.5 and Kir2.1 channels interact dynamically as part of membrane bound macromolecular complexes. OBJECTIVE:To test whether NaV1.5 and Kir2.1 preassemble during early forward trafficking and travel together to common membrane microdomains. METHODS AND RESULTS:In patch-...

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Veröffentlicht in:	Circulation research 2018-05, Vol.122 (11), p.1501-1516
Hauptverfasser:	Ponce-Balbuena, Daniela, Guerrero-Serna, Guadalupe, Valdivia, Carmen R, Caballero, Ricardo, Diez-Guerra, F Javier, Jiménez-Vázquez, Eric N, Ramírez, Rafael J, da Rocha, André Monteiro, Herron, Todd J, Campbell, Katherine F, Willis, B Cicero, Alvarado, Francisco J, Zarzoso, Manuel, Kaur, Kuljeet, Pérez-Hernández, Marta, Matamoros, Marcos, Valdivia, Héctor H, Delpón, Eva, Jalife, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Adaptin Biotinylation Cardiac muscle Cardiomyocytes Cell surface Clathrin Coated vesicles Coronary artery disease Deficient mutant Depolarization Excitability Experiments Fluorescence recovery after photobleaching Gene transfer Glycosylation Golgi apparatus Heart diseases Macromolecules Mobility Myocytes Pluripotency Potassium Potassium channels (inwardly-rectifying) Site-directed mutagenesis Stem cells Transcription factors Tubules Ventricle
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