A facile approach to enhance antigen response for personalized cancer vaccination

Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration, which, beyond practical issues, may impact peptide presentation and result in vaccine variability. Here, we report a simple adsorption approach using polyethyleneimine (PEI) in a...

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Veröffentlicht in:	Nature materials 2018-06, Vol.17 (6), p.528-534
Hauptverfasser:	Li, Aileen Weiwei, Sobral, Miguel C., Badrinath, Soumya, Choi, Youngjin, Graveline, Amanda, Stafford, Alexander G., Weaver, James C., Dellacherie, Maxence O., Shih, Ting-Yu, Ali, Omar A., Kim, Jaeyun, Wucherpfennig, Kai W., Mooney, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61/24 631/61/54 Animals Antigens Antigens, Neoplasm - immunology Biomaterials Cancer Cancer Vaccines - chemistry Cancer Vaccines - immunology Cell Line, Tumor Chemistry and Materials Science Condensed Matter Physics Drug Compounding Drug delivery systems Formulations Humans Immunization Immunogenicity Immunology Letter Lung cancer Materials Science Mice Nanotechnology Optical and Electronic Materials Peptides Polyethyleneimine Precision Medicine Silica Silicon dioxide T cell receptors Tumors Vaccination Vaccines
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