Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults
We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders. We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, m...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-03, Vol.72 (3), p.431-437 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Nadkarni, Neelesh K Lopez, Oscar L Perera, Subashan Studenski, Stephanie A Snitz, Beth E Erickson, Kirk I Mathis, Chester A Nebes, Robert D Redfern, Mark Klunk, William E |
| description | We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders.
We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements.
PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p < .05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, Aβ was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance.
Preliminary evidence indicates that cerebral Aβ is associated with gait slowing on dual-tasking in healthy older adults. |
| doi_str_mv | 10.1093/gerona/glw211 |
| format | Article |
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We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements.
PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p < .05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, Aβ was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance.
Preliminary evidence indicates that cerebral Aβ is associated with gait slowing on dual-tasking in healthy older adults.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glw211</identifier><identifier>PMID: 27803098</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Amyloid beta-Peptides - metabolism ; Brain ; Brain - metabolism ; Cognition & reasoning ; Cognition - physiology ; Female ; Gait - physiology ; Human performance ; Humans ; Male ; Mobility ; NMR ; Nuclear magnetic resonance ; Older people ; Task Performance and Analysis</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2017-03, Vol.72 (3), p.431-437</ispartof><rights>The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Mar 2017</rights><rights>The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-d5a0c2c012dea9576662ac4dfd42e452b1c8a63eaab3a4b67bed21aa5130e8b3</citedby><cites>FETCH-LOGICAL-c415t-d5a0c2c012dea9576662ac4dfd42e452b1c8a63eaab3a4b67bed21aa5130e8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27803098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nadkarni, Neelesh K</creatorcontrib><creatorcontrib>Lopez, Oscar L</creatorcontrib><creatorcontrib>Perera, Subashan</creatorcontrib><creatorcontrib>Studenski, Stephanie A</creatorcontrib><creatorcontrib>Snitz, Beth E</creatorcontrib><creatorcontrib>Erickson, Kirk I</creatorcontrib><creatorcontrib>Mathis, Chester A</creatorcontrib><creatorcontrib>Nebes, Robert D</creatorcontrib><creatorcontrib>Redfern, Mark</creatorcontrib><creatorcontrib>Klunk, William E</creatorcontrib><title>Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders.
We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements.
PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p < .05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, Aβ was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance.
Preliminary evidence indicates that cerebral Aβ is associated with gait slowing on dual-tasking in healthy older adults.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Female</subject><subject>Gait - physiology</subject><subject>Human performance</subject><subject>Humans</subject><subject>Male</subject><subject>Mobility</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Older people</subject><subject>Task Performance and Analysis</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1v1DAQxS0EoqVw5IosceFAqD_ixLkgrZZPqaWXReJmTeLZ4OLYWztptf89rrZUpXOZGc1PT_P0CHnN2QfOOnk6YooBTkd_Izh_Qo55q3SlpPr1tMys7SrFWHNEXuR8yW5LiefkSLSaSdbpY2LXmLBP4Olq2vvoLP2Eu5jd7GKgEMq6gK82kP-4MFIX6DqOoVyv0e_pj5gm8O_peeydd_Oe_gxu2oFLaOmFt5joyi5-zi_Jsy34jK_u-gnZfPm8WX-rzi6-fl-vzqqh5mqurAI2iIFxYRE61TZNI2Co7dbWAmslej5oaCQC9BLqvml7tIIDKC4Z6l6ekI8H2d3ST2gHDHMxZnbJTZD2JoIz_1-C-23GeG1U1-hG1kXg3Z1AilcL5tlMLg_oPQSMSzZcS6Vk2-quoG8foZdxSaG4K1TLuG6E1IWqDtSQYs4Jt_fPcGZu4zOH-MwhvsK_eejgnv6Xl_wLxIqabQ</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Nadkarni, Neelesh K</creator><creator>Lopez, Oscar L</creator><creator>Perera, Subashan</creator><creator>Studenski, Stephanie A</creator><creator>Snitz, Beth E</creator><creator>Erickson, Kirk I</creator><creator>Mathis, Chester A</creator><creator>Nebes, Robert D</creator><creator>Redfern, Mark</creator><creator>Klunk, William E</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170301</creationdate><title>Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults</title><author>Nadkarni, Neelesh K ; Lopez, Oscar L ; Perera, Subashan ; Studenski, Stephanie A ; Snitz, Beth E ; Erickson, Kirk I ; Mathis, Chester A ; Nebes, Robert D ; Redfern, Mark ; Klunk, William E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-d5a0c2c012dea9576662ac4dfd42e452b1c8a63eaab3a4b67bed21aa5130e8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Cognition & reasoning</topic><topic>Cognition - physiology</topic><topic>Female</topic><topic>Gait - physiology</topic><topic>Human performance</topic><topic>Humans</topic><topic>Male</topic><topic>Mobility</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Older people</topic><topic>Task Performance and Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadkarni, Neelesh K</creatorcontrib><creatorcontrib>Lopez, Oscar L</creatorcontrib><creatorcontrib>Perera, Subashan</creatorcontrib><creatorcontrib>Studenski, Stephanie A</creatorcontrib><creatorcontrib>Snitz, Beth E</creatorcontrib><creatorcontrib>Erickson, Kirk I</creatorcontrib><creatorcontrib>Mathis, Chester A</creatorcontrib><creatorcontrib>Nebes, Robert D</creatorcontrib><creatorcontrib>Redfern, Mark</creatorcontrib><creatorcontrib>Klunk, William E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. 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Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>72</volume><issue>3</issue><spage>431</spage><epage>437</epage><pages>431-437</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders.
We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements.
PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p < .05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, Aβ was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance.
Preliminary evidence indicates that cerebral Aβ is associated with gait slowing on dual-tasking in healthy older adults.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>27803098</pmid><doi>10.1093/gerona/glw211</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Amyloid beta-Peptides - metabolism Brain Brain - metabolism Cognition & reasoning Cognition - physiology Female Gait - physiology Human performance Humans Male Mobility NMR Nuclear magnetic resonance Older people Task Performance and Analysis |
| title | Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults |
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