Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease-driving mechanisms downstream of genomic alterations, includ...

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Veröffentlicht in:	Cancer discovery 2018-05, Vol.8 (5), p.582-599
Hauptverfasser:	Rajbhandari, Presha, Lopez, Gonzalo, Capdevila, Claudia, Salvatori, Beatrice, Yu, Jiyang, Rodriguez-Barrueco, Ruth, Martinez, Daniel, Yarmarkovich, Mark, Weichert-Leahey, Nina, Abraham, Brian J, Alvarez, Mariano J, Iyer, Archana, Harenza, Jo Lynne, Oldridge, Derek, De Preter, Katleen, Koster, Jan, Asgharzadeh, Shahab, Seeger, Robert C, Wei, Jun S, Khan, Javed, Vandesompele, Jo, Mestdagh, Pieter, Versteeg, Rogier, Look, A Thomas, Young, Richard A, Iavarone, Antonio, Lasorella, Anna, Silva, Jose M, Maris, John M, Califano, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases Cell Cycle Proteins Cell Line, Tumor Computational Biology - methods DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Muscle Proteins - genetics Muscle Proteins - metabolism N-Myc Proto-Oncogene Protein - genetics N-Myc Proto-Oncogene Protein - metabolism Neoplasm Staging Neuroblastoma - diagnosis Neuroblastoma - genetics Neuroblastoma - metabolism Nuclear Proteins - metabolism Proteasome Endopeptidase Complex - metabolism Regulatory Sequences, Nucleic Acid RNA Interference TEA Domain Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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