Use of succinic & oxalic acid in reducing the dosage of colistin against New Delhi metallo-β-lactamase-1 bacteria

Background & objectives: New Delhi metallo-β-lactamase 1 (NDM-1) cleaves the beta-lactam ring, and confers bacterial resistance against most of the beta-lactam antibiotics, except tigecycline and colistin. Among these two antibiotics, colistin is considered toxic, and therefore, its clinical use...

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Veröffentlicht in:	Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2018-01, Vol.147 (1), p.97-101
Hauptverfasser:	Kumar, Ravichandiran, Chandar, Brinda, Parani, Madasamy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacteria Bacterial infections beta-Lactamases - drug effects Carbapenems - pharmacology Colistin - pharmacology Drug dosages Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Drug Synergism E coli Enzymes Escherichia coli - drug effects Escherichia coli - enzymology Humans Infections Laboratories Microbial Sensitivity Tests Multidrug resistant organisms Original Oxalic Acid - pharmacology Succinic Acid - pharmacology Toxicity
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