PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells

Age-related macular degeneration (AMD) is the leading cause of vision loss among the elderly population, and is associated with severe macular degeneration and choroidal neovascularization (CNV). Although the pathogenesis of AMD is associated with choroidal dysfunction and CNV, the detailed underlyi...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2018-04, Vol.314 (4), p.C456-C472
Hauptverfasser:	Farnoodian, Mitra, Sorenson, Christine M, Sheibani, Nader
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Adhesion Cell Movement Cell Proliferation Cells, Cultured Choroid - blood supply Choroidal Neovascularization - genetics Choroidal Neovascularization - metabolism Choroidal Neovascularization - pathology Cytokines - metabolism Endothelial Cells - metabolism Endothelial Cells - pathology Eye Proteins - genetics Eye Proteins - metabolism Inflammation Mediators - metabolism Macular Degeneration - genetics Macular Degeneration - metabolism Macular Degeneration - pathology Mice, Inbred C57BL Mice, Knockout Nerve Growth Factors - deficiency Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Osteopontin - metabolism Oxidative Stress Serpins - deficiency Serpins - genetics Serpins - metabolism Vascular Endothelial Growth Factor A - metabolism
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