Fetal growth and incidence of atopic dermatitis in early childhood: Results of the Ulm SPATZ Health Study
Fetal growth may be a precursory factor in observed association between birthweight and atopic dermatitis (AD), however, recent studies utilizing fetal ultrasound-based data have reported contradictory results. This study aims to clarify previous findings through comprehensive investigation of assoc...
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| Veröffentlicht in: | Scientific reports 2018-05, Vol.8 (1), p.8041-8, Article 8041 |
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| description | Fetal growth may be a precursory factor in observed association between birthweight and atopic dermatitis (AD), however, recent studies utilizing fetal ultrasound-based data have reported contradictory results. This study aims to clarify previous findings through comprehensive investigation of association between several trimester-specific ultrasound-based anthropometric measures with AD diagnosis by age 3 years. Measurements of 386 newborns in the Ulm SPATZ Health Study were converted into adjusted z-scores categorized as “low” (≤1 SD below mean), “normal,” or “high” (≥1 SD above mean). AD cases were defined using parent- or pediatrician-report of physician-diagnosis or clinical diagnosis. Adjusted risk ratios (RR) with 95% confidence intervals (95% CI) were calculated using modified Poisson regression. Compared to normal, both low and high 2
nd
trimester abdominal circumference [RR 1.51, (95% CI 1.01; 2.24) and 1.83 (1.21; 2.76)], high 2
nd
trimester head- abdominal circumference ratio [1.69 (1.16; 2.48)], and faltering 2
nd
to 3
rd
trimester [1.59 (1.04; 2.43)] head circumference were associated with greater AD risk. High 3
rd
trimester femur length [0.54 (0.31; 0.94)] was associated with lower risk. Using more inclusive exposure cut-points (0.8 SD), lower 1
st
trimester crown-rump length was also associated with greater AD risk. Our data suggest several different patterns of fetal growth may be differentially associated with AD. |
| doi_str_mv | 10.1038/s41598-018-26440-2 |
| format | Article |
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nd
trimester abdominal circumference [RR 1.51, (95% CI 1.01; 2.24) and 1.83 (1.21; 2.76)], high 2
nd
trimester head- abdominal circumference ratio [1.69 (1.16; 2.48)], and faltering 2
nd
to 3
rd
trimester [1.59 (1.04; 2.43)] head circumference were associated with greater AD risk. High 3
rd
trimester femur length [0.54 (0.31; 0.94)] was associated with lower risk. Using more inclusive exposure cut-points (0.8 SD), lower 1
st
trimester crown-rump length was also associated with greater AD risk. Our data suggest several different patterns of fetal growth may be differentially associated with AD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-26440-2</identifier><identifier>PMID: 29795189</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/699/249/2510/1415 ; Atopic dermatitis ; Birth weight ; Childhood ; Children ; Dermatitis ; Diagnosis ; Eczema ; Femur ; Fetuses ; Health risk assessment ; Humanities and Social Sciences ; multidisciplinary ; Neonates ; Science ; Science (multidisciplinary) ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Scientific reports, 2018-05, Vol.8 (1), p.8041-8, Article 8041</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-ceeb5b1ab593e8151cc5afb85c11688346b7956af405ace24fe95f7f69f081963</citedby><cites>FETCH-LOGICAL-c522t-ceeb5b1ab593e8151cc5afb85c11688346b7956af405ace24fe95f7f69f081963</cites><orcidid>0000-0001-5764-1528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966404/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966404/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29795189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Logan, Chad A.</creatorcontrib><creatorcontrib>Weiss, Johannes M.</creatorcontrib><creatorcontrib>Reister, Frank</creatorcontrib><creatorcontrib>Rothenbacher, Dietrich</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><title>Fetal growth and incidence of atopic dermatitis in early childhood: Results of the Ulm SPATZ Health Study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Fetal growth may be a precursory factor in observed association between birthweight and atopic dermatitis (AD), however, recent studies utilizing fetal ultrasound-based data have reported contradictory results. This study aims to clarify previous findings through comprehensive investigation of association between several trimester-specific ultrasound-based anthropometric measures with AD diagnosis by age 3 years. Measurements of 386 newborns in the Ulm SPATZ Health Study were converted into adjusted z-scores categorized as “low” (≤1 SD below mean), “normal,” or “high” (≥1 SD above mean). AD cases were defined using parent- or pediatrician-report of physician-diagnosis or clinical diagnosis. Adjusted risk ratios (RR) with 95% confidence intervals (95% CI) were calculated using modified Poisson regression. Compared to normal, both low and high 2
nd
trimester abdominal circumference [RR 1.51, (95% CI 1.01; 2.24) and 1.83 (1.21; 2.76)], high 2
nd
trimester head- abdominal circumference ratio [1.69 (1.16; 2.48)], and faltering 2
nd
to 3
rd
trimester [1.59 (1.04; 2.43)] head circumference were associated with greater AD risk. High 3
rd
trimester femur length [0.54 (0.31; 0.94)] was associated with lower risk. Using more inclusive exposure cut-points (0.8 SD), lower 1
st
trimester crown-rump length was also associated with greater AD risk. Our data suggest several different patterns of fetal growth may be differentially associated with AD.</description><subject>692/308/174</subject><subject>692/699/249/2510/1415</subject><subject>Atopic dermatitis</subject><subject>Birth weight</subject><subject>Childhood</subject><subject>Children</subject><subject>Dermatitis</subject><subject>Diagnosis</subject><subject>Eczema</subject><subject>Femur</subject><subject>Fetuses</subject><subject>Health risk assessment</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Neonates</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UUtPFTEUnhiNEOQPuDBN3LgZbDtt79SFCSECJiQSgY2bptM5vVPSmV7bjuT-ezpeRHRBN6fJ9ziPr6reEnxEcNN-TIxw2daYtDUVjOGavqj2KWa8pg2lL5_896rDlG5xeZxKRuTrao_KleSklfuVO4WsPVrHcJcHpKceucm4HiYDKFikc9g4g3qIo84uu1RgBDr6LTKD8_0QQv8JfYc0-5wWQR4A3fgRXV0eX_9A56B9sb3Kc799U72y2ic4fKgH1c3pl-uT8_ri29nXk-OL2nBKc20AOt4R3XHZQEs4MYZr27XcECLatmGiK7MLbRnm2gBlFiS3KyukxS2RojmoPu98N3M3Qm9gylF7tYlu1HGrgnbqX2Ryg1qHX4pLIRhmxeDDg0EMP2dIWY0uGfBeTxDmpJbD0hVlYun1_j_qbZjjVNZbWA3h5eSLId2xTAwpRbCPwxCsljDVLkxVwlS_w1S0iN49XeNR8ie6Qmh2hFSgaQ3xb-9nbO8BF72qlA</recordid><startdate>20180523</startdate><enddate>20180523</enddate><creator>Logan, Chad A.</creator><creator>Weiss, Johannes M.</creator><creator>Reister, Frank</creator><creator>Rothenbacher, Dietrich</creator><creator>Genuneit, Jon</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5764-1528</orcidid></search><sort><creationdate>20180523</creationdate><title>Fetal growth and incidence of atopic dermatitis in early childhood: Results of the Ulm SPATZ Health Study</title><author>Logan, Chad A. ; Weiss, Johannes M. ; Reister, Frank ; Rothenbacher, Dietrich ; Genuneit, Jon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-ceeb5b1ab593e8151cc5afb85c11688346b7956af405ace24fe95f7f69f081963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/308/174</topic><topic>692/699/249/2510/1415</topic><topic>Atopic dermatitis</topic><topic>Birth weight</topic><topic>Childhood</topic><topic>Children</topic><topic>Dermatitis</topic><topic>Diagnosis</topic><topic>Eczema</topic><topic>Femur</topic><topic>Fetuses</topic><topic>Health risk assessment</topic><topic>Humanities and Social Sciences</topic><topic>multidisciplinary</topic><topic>Neonates</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Logan, Chad A.</creatorcontrib><creatorcontrib>Weiss, Johannes M.</creatorcontrib><creatorcontrib>Reister, Frank</creatorcontrib><creatorcontrib>Rothenbacher, Dietrich</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Logan, Chad A.</au><au>Weiss, Johannes M.</au><au>Reister, Frank</au><au>Rothenbacher, Dietrich</au><au>Genuneit, Jon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal growth and incidence of atopic dermatitis in early childhood: Results of the Ulm SPATZ Health Study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-05-23</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>8041</spage><epage>8</epage><pages>8041-8</pages><artnum>8041</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Fetal growth may be a precursory factor in observed association between birthweight and atopic dermatitis (AD), however, recent studies utilizing fetal ultrasound-based data have reported contradictory results. This study aims to clarify previous findings through comprehensive investigation of association between several trimester-specific ultrasound-based anthropometric measures with AD diagnosis by age 3 years. Measurements of 386 newborns in the Ulm SPATZ Health Study were converted into adjusted z-scores categorized as “low” (≤1 SD below mean), “normal,” or “high” (≥1 SD above mean). AD cases were defined using parent- or pediatrician-report of physician-diagnosis or clinical diagnosis. Adjusted risk ratios (RR) with 95% confidence intervals (95% CI) were calculated using modified Poisson regression. Compared to normal, both low and high 2
nd
trimester abdominal circumference [RR 1.51, (95% CI 1.01; 2.24) and 1.83 (1.21; 2.76)], high 2
nd
trimester head- abdominal circumference ratio [1.69 (1.16; 2.48)], and faltering 2
nd
to 3
rd
trimester [1.59 (1.04; 2.43)] head circumference were associated with greater AD risk. High 3
rd
trimester femur length [0.54 (0.31; 0.94)] was associated with lower risk. Using more inclusive exposure cut-points (0.8 SD), lower 1
st
trimester crown-rump length was also associated with greater AD risk. Our data suggest several different patterns of fetal growth may be differentially associated with AD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29795189</pmid><doi>10.1038/s41598-018-26440-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5764-1528</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/174 692/699/249/2510/1415 Atopic dermatitis Birth weight Childhood Children Dermatitis Diagnosis Eczema Femur Fetuses Health risk assessment Humanities and Social Sciences multidisciplinary Neonates Science Science (multidisciplinary) Ultrasonic imaging Ultrasound |
| title | Fetal growth and incidence of atopic dermatitis in early childhood: Results of the Ulm SPATZ Health Study |
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