Genetic variation in P2RX7 and pain tolerance

P2X7 is a nonselective cation channel activated by extracellular ATP. P2X7 activation contributes to the proinflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been linked to chronic inflammatory and neuropathic pain. P2X7 may contribute to pain...

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Veröffentlicht in:	Pain (Amsterdam) 2018-06, Vol.159 (6), p.1064-1073
Hauptverfasser:	Kambur, Oleg, Kaunisto, Mari A., Winsvold, Bendik S., Wilsgaard, Tom, Stubhaug, Audun, Zwart, John A., Kalso, Eija, Nielsen, Christopher S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Clinical medical disciplines: 750 Cohort Studies Cold-pressor test Community Health Planning Cross-Sectional Studies DNA Mutational Analysis Experimental pain Female Genetic Variation - genetics Genotype Humans Klinisk medisinske fag: 750 Male Medical disciplines: 700 Medisinske Fag: 700 Middle Aged Neurology: 752 Nevrologi: 752 P2X7 Pain - etiology Pain - genetics Pain - physiopathology Pain Measurement Pain Threshold - physiology Polymorphism Receptors, Purinergic P2X7 - genetics Research Paper Sex Factors SNP VDP Young Adult
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