T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV‐1 patients

Introduction: Restriction factors (RFs) suppress HIV‐1 in cell lines and primary cell models. Hence, RFs might be attractive targets for novel antiviral strategies, but their importance for virus control in vivo is controversial. Methods: We profiled the expression of RFs in primary blood‐derived mo...

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Veröffentlicht in:	Journal of the International AIDS Society 2017, Vol.20 (1), p.21865-n/a
Hauptverfasser:	Bolduan, Sebastian, Koppensteiner, Herwig, Businger, Ramona, Rebensburg, Stephanie, Kunze, Christine, Brack‐Werner, Ruth, Draenert, Rika, Schindler, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult Aged AIDS AIDS/HIV Antiviral agents Cells Cloning Control Dosage and administration Drug therapy Experiments Female Health aspects Hepatitis HIV HIV infections HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV patients HIV-1 - physiology HIV‐1 Human immunodeficiency virus Humans Immune system in vivo relevance Infections Interferon Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - virology Lymphocytes Male Middle Aged p21 Patients Physiological aspects Proteins restriction factors RISP SAM Domain and HD Domain-Containing Protein 1 - genetics SAM Domain and HD Domain-Containing Protein 1 - immunology SAMHD1 SerinC5 T cells T-Lymphocytes - immunology T-Lymphocytes - virology Tetherin Viral Load Viruses
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