A Comparative Study for Detection of EGFR Mutations in Plasma Cell-Free DNA in Korean Clinical Diagnostic Laboratories

Liquid biopsies to genotype the epidermal growth factor receptor (EGFR) for targeted therapy have been implemented in clinical decision-making in the field of lung cancer, but harmonization of detection methods is still scarce among clinical laboratories. We performed a pilot external quality assura...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-11
Hauptverfasser:	Kim, Yoonjung, Lee, Kyung-A, Shin, Saeam
Format:	Artikel
Sprache:	eng
Schlagworte:	Assaying Biological Assay - methods Biotechnology industry Cell-Free Nucleic Acids - blood Clinical Laboratory Techniques - methods Clonal deletion Comparative analysis Comparative studies Decision making Deoxyribonucleic acid Diagnostic equipment (Medical) Diagnostic systems DNA DNA testing DNA, Neoplasm - blood Epidermal growth factor Epidermal growth factor receptors Ethylenediaminetetraacetic acid Exons - genetics Gene frequency Gene Frequency - genetics Genetic aspects Genotype Genotypes High-Throughput Nucleotide Sequencing - methods Humans Insertion Instrument industry Laboratories Limit of Detection Lung cancer Medical laboratories Molecular chains Mutation Mutation - genetics Plasma - chemistry Quality assurance Quality control Receptor, Epidermal Growth Factor - blood Receptor, Epidermal Growth Factor - genetics Reproducibility Reproducibility of Results Republic of Korea Scientific equipment and supplies industry Sequence Deletion - genetics Systems analysis Target detection
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