Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the degeneration of upper and lower motor neurons. Defects in axonal transport have been observed pre-symptomatically in the SOD1 G93A mouse model of ALS, and have been proposed to play a role in motor neuron degenera...

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Veröffentlicht in:	Cell death & disease 2018-05, Vol.9 (6), p.596-16, Article 596
Hauptverfasser:	Gibbs, Katherine L., Kalmar, Bernadett, Rhymes, Elena R., Fellows, Alexander D., Ahmed, Mahmood, Whiting, Paul, Davies, Ceri H., Greensmith, Linda, Schiavo, Giampietro
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/95 14 14/34 59 64/110 82 Acetylcarnitine - pharmacology Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - enzymology Amyotrophic Lateral Sclerosis - pathology Animals Antibodies Axonal transport Axonal Transport - drug effects Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Disease Models, Animal Endosomes Enzyme Activation - drug effects Hindlimb - drug effects Hindlimb - physiopathology Imidazoles - pharmacology Immunology JNK Mitogen-Activated Protein Kinases - metabolism Kinases Life Sciences MAP kinase Mice, Inbred C57BL Mice, Transgenic Motor neurons Motor Neurons - drug effects Motor Neurons - metabolism Muscles - drug effects Muscles - physiopathology Nervous system Neurodegeneration Neurons Neuropathy p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Quinazolinones - pharmacology Receptors, Nerve Growth Factor - metabolism Retrograde transport Superoxide Dismutase - metabolism Tetanus Toxin - metabolism
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