Numerical Simulation of Stent Angioplasty with Predilation: An Investigation into Lesion Constitutive Representation and Calcification Influence
It is acceptable clinical practice to predilate a severely occluded vessel to allow better positioning of endovascular stents, and while the impact of this intervention has been examined for aggregate response in animals there has been no means to examine whether there are specific vessels that migh...
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| Veröffentlicht in: | Annals of biomedical engineering 2017-09, Vol.45 (9), p.2244-2252 |
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| creator | Conway, C. McGarry, J. P. Edelman, E. R. McHugh, P. E. |
| description | It is acceptable clinical practice to predilate a severely occluded vessel to allow better positioning of endovascular stents, and while the impact of this intervention has been examined for aggregate response in animals there has been no means to examine whether there are specific vessels that might benefit. Finite element methods offer the singular ability to explore the mechanical response of arteries with specific pathologic alterations in mechanics to stenting and predilation. We examined varying representations of atherosclerotic tissue including homogeneous and heterogeneous dispersion of calcified particles, and elastic, pseudo-elastic, and elastic–plastic constitutive representations of bulk atherosclerotic tissue. The constitutive representations of the bulk atherosclerotic tissue were derived from experimental test data and highlight the importance of accounting for testing mode of loading. The impact of arterial predilation is presented and, in particular, its effect on intimal predicted damage, atherosclerotic tissue von Mises and maximum principal stresses, and luminal deformation was dependent on the type of constitutive representation of diseased tissue, particularly in the presence of calcifications. |
| doi_str_mv | 10.1007/s10439-017-1851-3 |
| format | Article |
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The constitutive representations of the bulk atherosclerotic tissue were derived from experimental test data and highlight the importance of accounting for testing mode of loading. The impact of arterial predilation is presented and, in particular, its effect on intimal predicted damage, atherosclerotic tissue von Mises and maximum principal stresses, and luminal deformation was dependent on the type of constitutive representation of diseased tissue, particularly in the presence of calcifications.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-017-1851-3</identifier><identifier>PMID: 28488215</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Angioplasty ; Arteries ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - physiopathology ; Atherosclerosis - surgery ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Blood vessels ; Calcification ; Cardiovascular system ; Classical Mechanics ; Computer Simulation ; Deformation ; Finite element method ; Humans ; Implants ; Mathematical models ; Mechanical analysis ; Models, Cardiovascular ; Plastics ; Representations ; Stents ; Surgical implants ; Tissues ; Vascular Calcification - pathology ; Vascular Calcification - physiopathology ; Vascular Calcification - surgery ; Vasodilation</subject><ispartof>Annals of biomedical engineering, 2017-09, Vol.45 (9), p.2244-2252</ispartof><rights>Biomedical Engineering Society 2017</rights><rights>Annals of Biomedical Engineering is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-4f0a9e2aebe04cda0b58317a63f5ad619cef95afdab5b87fe68e7c4fcfed0b63</citedby><cites>FETCH-LOGICAL-c470t-4f0a9e2aebe04cda0b58317a63f5ad619cef95afdab5b87fe68e7c4fcfed0b63</cites><orcidid>0000-0003-4236-2280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-017-1851-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-017-1851-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28488215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conway, C.</creatorcontrib><creatorcontrib>McGarry, J. P.</creatorcontrib><creatorcontrib>Edelman, E. R.</creatorcontrib><creatorcontrib>McHugh, P. E.</creatorcontrib><title>Numerical Simulation of Stent Angioplasty with Predilation: An Investigation into Lesion Constitutive Representation and Calcification Influence</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>It is acceptable clinical practice to predilate a severely occluded vessel to allow better positioning of endovascular stents, and while the impact of this intervention has been examined for aggregate response in animals there has been no means to examine whether there are specific vessels that might benefit. Finite element methods offer the singular ability to explore the mechanical response of arteries with specific pathologic alterations in mechanics to stenting and predilation. We examined varying representations of atherosclerotic tissue including homogeneous and heterogeneous dispersion of calcified particles, and elastic, pseudo-elastic, and elastic–plastic constitutive representations of bulk atherosclerotic tissue. The constitutive representations of the bulk atherosclerotic tissue were derived from experimental test data and highlight the importance of accounting for testing mode of loading. 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P.</au><au>Edelman, E. R.</au><au>McHugh, P. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Numerical Simulation of Stent Angioplasty with Predilation: An Investigation into Lesion Constitutive Representation and Calcification Influence</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>45</volume><issue>9</issue><spage>2244</spage><epage>2252</epage><pages>2244-2252</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>It is acceptable clinical practice to predilate a severely occluded vessel to allow better positioning of endovascular stents, and while the impact of this intervention has been examined for aggregate response in animals there has been no means to examine whether there are specific vessels that might benefit. Finite element methods offer the singular ability to explore the mechanical response of arteries with specific pathologic alterations in mechanics to stenting and predilation. We examined varying representations of atherosclerotic tissue including homogeneous and heterogeneous dispersion of calcified particles, and elastic, pseudo-elastic, and elastic–plastic constitutive representations of bulk atherosclerotic tissue. The constitutive representations of the bulk atherosclerotic tissue were derived from experimental test data and highlight the importance of accounting for testing mode of loading. 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| subjects | Angioplasty Arteries Arteriosclerosis Atherosclerosis Atherosclerosis - physiopathology Atherosclerosis - surgery Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Blood vessels Calcification Cardiovascular system Classical Mechanics Computer Simulation Deformation Finite element method Humans Implants Mathematical models Mechanical analysis Models, Cardiovascular Plastics Representations Stents Surgical implants Tissues Vascular Calcification - pathology Vascular Calcification - physiopathology Vascular Calcification - surgery Vasodilation |
| title | Numerical Simulation of Stent Angioplasty with Predilation: An Investigation into Lesion Constitutive Representation and Calcification Influence |
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