Highly Bactericidal Macroporous Antimicrobial Polymeric Gel for Point-of-Use Water Disinfection
Access to clean and safe water supply remains inadequate in many developing countries. One of the key challenges is to remove pathogenic bacteria from the water supply via effective water disinfection technologies to prevent the spread of diseases and to ensure the safety of consumers. Herein, a hig...
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description | Access to clean and safe water supply remains inadequate in many developing countries. One of the key challenges is to remove pathogenic bacteria from the water supply via effective water disinfection technologies to prevent the spread of diseases and to ensure the safety of consumers. Herein, a highly effective point-of-use (on-demand) water disinfection technology, in the form of a polymeric scaffold called macroporous antimicrobial polymeric gel (MAPG), is demonstrated. MAPG is easy to fabricate, completely organic and possess inherent antimicrobial property which makes it non-reliant on inorganic compounds such as silver where the long-term toxicity remains unknown. MAPG is highly bactericidal and can disinfect bacteria-contaminated water (ca. 10
8
CFU mL
−1
) at a capacity of about >50 times the mass of the organic material used, inactivating >99% of both Gram-negative and Gram-positive bacteria including
Escherichia coli
,
Vibrio cholerae
and
Staphylococcus aureus
within 20 minutes of treatment. When fabricated in a syringe, MAPG eliminates
E. coli
from contaminated water source by >8.0 log
10
reduction in bacteria counts (i.e., no viable bacteria were detected after treatment), and the syringe can be reused multiple times without losing potency. The MAPG technology is not only restricted to water disinfection but may also be applicable in other bacteria inactivation applications. |
doi_str_mv | 10.1038/s41598-018-26202-0 |
format | Article |
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8
CFU mL
−1
) at a capacity of about >50 times the mass of the organic material used, inactivating >99% of both Gram-negative and Gram-positive bacteria including
Escherichia coli
,
Vibrio cholerae
and
Staphylococcus aureus
within 20 minutes of treatment. When fabricated in a syringe, MAPG eliminates
E. coli
from contaminated water source by >8.0 log
10
reduction in bacteria counts (i.e., no viable bacteria were detected after treatment), and the syringe can be reused multiple times without losing potency. The MAPG technology is not only restricted to water disinfection but may also be applicable in other bacteria inactivation applications.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-26202-0</identifier><identifier>PMID: 29785029</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/106 ; 140/131 ; 639/301/923/1028 ; 639/638/298/923/1027 ; Anti-Bacterial Agents - pharmacology ; Antimicrobial agents ; Bacteria ; Bacteria - drug effects ; Developing countries ; Disinfectants - pharmacology ; Disinfection ; Escherichia coli ; Gels ; Gram-positive bacteria ; Humanities and Social Sciences ; Inorganic compounds ; LDCs ; multidisciplinary ; Point-of-Care Testing - statistics & numerical data ; Polymers - pharmacology ; Science ; Science (multidisciplinary) ; Toxicity ; Water Microbiology ; Water Purification - methods ; Water shortages ; Water supply</subject><ispartof>Scientific reports, 2018-05, Vol.8 (1), p.7965-9, Article 7965</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-dada8dc3e3681b2e8a31eae8d7df73912464b24dd832fa4be50131130161020f3</citedby><cites>FETCH-LOGICAL-c577t-dada8dc3e3681b2e8a31eae8d7df73912464b24dd832fa4be50131130161020f3</cites><orcidid>0000-0001-5151-5045</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962547/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962547/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29785029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Amit</creatorcontrib><creatorcontrib>Boyer, Cyrille</creatorcontrib><creatorcontrib>Nebhani, Leena</creatorcontrib><creatorcontrib>Wong, Edgar H. H.</creatorcontrib><title>Highly Bactericidal Macroporous Antimicrobial Polymeric Gel for Point-of-Use Water Disinfection</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Access to clean and safe water supply remains inadequate in many developing countries. One of the key challenges is to remove pathogenic bacteria from the water supply via effective water disinfection technologies to prevent the spread of diseases and to ensure the safety of consumers. Herein, a highly effective point-of-use (on-demand) water disinfection technology, in the form of a polymeric scaffold called macroporous antimicrobial polymeric gel (MAPG), is demonstrated. MAPG is easy to fabricate, completely organic and possess inherent antimicrobial property which makes it non-reliant on inorganic compounds such as silver where the long-term toxicity remains unknown. MAPG is highly bactericidal and can disinfect bacteria-contaminated water (ca. 10
8
CFU mL
−1
) at a capacity of about >50 times the mass of the organic material used, inactivating >99% of both Gram-negative and Gram-positive bacteria including
Escherichia coli
,
Vibrio cholerae
and
Staphylococcus aureus
within 20 minutes of treatment. When fabricated in a syringe, MAPG eliminates
E. coli
from contaminated water source by >8.0 log
10
reduction in bacteria counts (i.e., no viable bacteria were detected after treatment), and the syringe can be reused multiple times without losing potency. 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H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly Bactericidal Macroporous Antimicrobial Polymeric Gel for Point-of-Use Water Disinfection</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-05-21</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>7965</spage><epage>9</epage><pages>7965-9</pages><artnum>7965</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Access to clean and safe water supply remains inadequate in many developing countries. One of the key challenges is to remove pathogenic bacteria from the water supply via effective water disinfection technologies to prevent the spread of diseases and to ensure the safety of consumers. Herein, a highly effective point-of-use (on-demand) water disinfection technology, in the form of a polymeric scaffold called macroporous antimicrobial polymeric gel (MAPG), is demonstrated. MAPG is easy to fabricate, completely organic and possess inherent antimicrobial property which makes it non-reliant on inorganic compounds such as silver where the long-term toxicity remains unknown. MAPG is highly bactericidal and can disinfect bacteria-contaminated water (ca. 10
8
CFU mL
−1
) at a capacity of about >50 times the mass of the organic material used, inactivating >99% of both Gram-negative and Gram-positive bacteria including
Escherichia coli
,
Vibrio cholerae
and
Staphylococcus aureus
within 20 minutes of treatment. When fabricated in a syringe, MAPG eliminates
E. coli
from contaminated water source by >8.0 log
10
reduction in bacteria counts (i.e., no viable bacteria were detected after treatment), and the syringe can be reused multiple times without losing potency. The MAPG technology is not only restricted to water disinfection but may also be applicable in other bacteria inactivation applications.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29785029</pmid><doi>10.1038/s41598-018-26202-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5151-5045</orcidid><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Nature Free; PubMed; DOAJ Directory of Open Access Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library; Springer Nature OA Free Journals |
subjects | 13/106 140/131 639/301/923/1028 639/638/298/923/1027 Anti-Bacterial Agents - pharmacology Antimicrobial agents Bacteria Bacteria - drug effects Developing countries Disinfectants - pharmacology Disinfection Escherichia coli Gels Gram-positive bacteria Humanities and Social Sciences Inorganic compounds LDCs multidisciplinary Point-of-Care Testing - statistics & numerical data Polymers - pharmacology Science Science (multidisciplinary) Toxicity Water Microbiology Water Purification - methods Water shortages Water supply |
title | Highly Bactericidal Macroporous Antimicrobial Polymeric Gel for Point-of-Use Water Disinfection |
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