Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep
Previous attempts to improve growth and development of the intrauterine growth‐restricted (IUGR) foetus during pregnancy have not worked or caused harm. Our research identifies tissue‐specific mechanisms underlying foetal growth restriction and then tests strategies to improve growth and ameliorate...
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| Veröffentlicht in: | Acta Paediatrica 2016-08, Vol.105 (8), p.881-889 |
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| container_title | Acta Paediatrica |
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| creator | Hay Jr, William W. Brown, Laura D. Rozance, Paul J. Wesolowski, Stephanie R. Limesand, Sean W. |
| description | Previous attempts to improve growth and development of the intrauterine growth‐restricted (IUGR) foetus during pregnancy have not worked or caused harm. Our research identifies tissue‐specific mechanisms underlying foetal growth restriction and then tests strategies to improve growth and ameliorate many of the metabolic problems before the infant is born. The goal of our studies is to reduce the impact of foetal growth restriction at critical stages of development on the lifelong complications of IUGR offspring.
Conclusion
Defining specific mechanisms that cause growth restriction in the foetus might identify specific nutrients and hormones that could be given to the mother to improve foetal growth and reduce metabolic complications, using strategies first tested in our IUGR animal model. |
| doi_str_mv | 10.1111/apa.13413 |
| format | Article |
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Conclusion
Defining specific mechanisms that cause growth restriction in the foetus might identify specific nutrients and hormones that could be given to the mother to improve foetal growth and reduce metabolic complications, using strategies first tested in our IUGR animal model.</description><identifier>ISSN: 0803-5253</identifier><identifier>ISSN: 1651-2227</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.13413</identifier><identifier>PMID: 27028695</identifier><language>eng</language><publisher>Norway: Blackwell Publishing Ltd</publisher><subject>Amino acids ; Animals ; Blood Transfusion ; Erythrocytes - chemistry ; Female ; Fetal Growth Retardation - therapy ; Glucose ; Glucose - biosynthesis ; Insulin ; Insulin - metabolism ; Insulin Secretion ; Intrauterine growth restriction ; Liver - metabolism ; Metabolism ; Models, Animal ; Muscle, Skeletal - embryology ; Oxygen ; Oxygen - blood ; Pancreas - metabolism ; Placental Insufficiency - physiopathology ; Pregnancy ; Prenatal development ; Sheep</subject><ispartof>Acta Paediatrica, 2016-08, Vol.105 (8), p.881-889</ispartof><rights>2016 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 Foundation Acta Pædiatrica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5143-c2063cab00d5a816180b4c8f8ff6382dc079a076da2e8cfb160fac804919d1173</citedby><cites>FETCH-LOGICAL-c5143-c2063cab00d5a816180b4c8f8ff6382dc079a076da2e8cfb160fac804919d1173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.13413$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.13413$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27028695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hay Jr, William W.</creatorcontrib><creatorcontrib>Brown, Laura D.</creatorcontrib><creatorcontrib>Rozance, Paul J.</creatorcontrib><creatorcontrib>Wesolowski, Stephanie R.</creatorcontrib><creatorcontrib>Limesand, Sean W.</creatorcontrib><title>Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Previous attempts to improve growth and development of the intrauterine growth‐restricted (IUGR) foetus during pregnancy have not worked or caused harm. Our research identifies tissue‐specific mechanisms underlying foetal growth restriction and then tests strategies to improve growth and ameliorate many of the metabolic problems before the infant is born. The goal of our studies is to reduce the impact of foetal growth restriction at critical stages of development on the lifelong complications of IUGR offspring.
Conclusion
Defining specific mechanisms that cause growth restriction in the foetus might identify specific nutrients and hormones that could be given to the mother to improve foetal growth and reduce metabolic complications, using strategies first tested in our IUGR animal model.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Blood Transfusion</subject><subject>Erythrocytes - chemistry</subject><subject>Female</subject><subject>Fetal Growth Retardation - therapy</subject><subject>Glucose</subject><subject>Glucose - biosynthesis</subject><subject>Insulin</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Intrauterine growth restriction</subject><subject>Liver - metabolism</subject><subject>Metabolism</subject><subject>Models, Animal</subject><subject>Muscle, Skeletal - embryology</subject><subject>Oxygen</subject><subject>Oxygen - blood</subject><subject>Pancreas - metabolism</subject><subject>Placental Insufficiency - physiopathology</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Sheep</subject><issn>0803-5253</issn><issn>1651-2227</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstu1DAUhi0EokNhwQugSGzoIq0v8SUbpNGIFtBwk4q6tDzOycQlYw92Qul78MB4mnYESEj1wpbt7_z6j_0j9JzgY5LHidmaY8Iqwh6gGRGclJRS-RDNsMKs5JSzA_QkpUuMKasr8RgdUImpEjWfoV-LzvQ9-DWkwvnChzG61Dm_LoYO8skQzThAdB6KdQxXQ1dGSEN0doCmaAMMYyrKYgkpBZ-KHkz0u4sYNkUaxsZNsvfUMn2ROoDtU_SoNX2CZ7frIfp6-uZ88bZcfjp7t5gvS8tJxUpLsWDWrDBuuFFEEIVXlVWtalvBFG0slrXBUjSGgrLtigjcGqtwVZO6IUSyQ_R60t2Oqw00FnYWe72NbmPitQ7G6b9vvOv0OvzQvBakqqss8OpWIIbvY25Gb1yy0PfGQxiTzo6U4ApLfh-USpYnmtGX_6CX-Vt8fokbCkuF6535o4myMaQUod37JljvYqFzLPRNLDL74s9G9-RdDjJwMgFXrofr_yvp-ef5nWQ5Vbg0wM99hYnftJBMcn3x8Uy_P8dfLj7kjWC_AYfe1B4</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Hay Jr, William W.</creator><creator>Brown, Laura D.</creator><creator>Rozance, Paul J.</creator><creator>Wesolowski, Stephanie R.</creator><creator>Limesand, Sean W.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201608</creationdate><title>Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep</title><author>Hay Jr, William W. ; Brown, Laura D. ; Rozance, Paul J. ; Wesolowski, Stephanie R. ; Limesand, Sean W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5143-c2063cab00d5a816180b4c8f8ff6382dc079a076da2e8cfb160fac804919d1173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Blood Transfusion</topic><topic>Erythrocytes - chemistry</topic><topic>Female</topic><topic>Fetal Growth Retardation - therapy</topic><topic>Glucose</topic><topic>Glucose - biosynthesis</topic><topic>Insulin</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Intrauterine growth restriction</topic><topic>Liver - metabolism</topic><topic>Metabolism</topic><topic>Models, Animal</topic><topic>Muscle, Skeletal - embryology</topic><topic>Oxygen</topic><topic>Oxygen - blood</topic><topic>Pancreas - metabolism</topic><topic>Placental Insufficiency - physiopathology</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hay Jr, William W.</creatorcontrib><creatorcontrib>Brown, Laura D.</creatorcontrib><creatorcontrib>Rozance, Paul J.</creatorcontrib><creatorcontrib>Wesolowski, Stephanie R.</creatorcontrib><creatorcontrib>Limesand, Sean W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hay Jr, William W.</au><au>Brown, Laura D.</au><au>Rozance, Paul J.</au><au>Wesolowski, Stephanie R.</au><au>Limesand, Sean W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2016-08</date><risdate>2016</risdate><volume>105</volume><issue>8</issue><spage>881</spage><epage>889</epage><pages>881-889</pages><issn>0803-5253</issn><issn>1651-2227</issn><eissn>1651-2227</eissn><abstract>Previous attempts to improve growth and development of the intrauterine growth‐restricted (IUGR) foetus during pregnancy have not worked or caused harm. Our research identifies tissue‐specific mechanisms underlying foetal growth restriction and then tests strategies to improve growth and ameliorate many of the metabolic problems before the infant is born. The goal of our studies is to reduce the impact of foetal growth restriction at critical stages of development on the lifelong complications of IUGR offspring.
Conclusion
Defining specific mechanisms that cause growth restriction in the foetus might identify specific nutrients and hormones that could be given to the mother to improve foetal growth and reduce metabolic complications, using strategies first tested in our IUGR animal model.</abstract><cop>Norway</cop><pub>Blackwell Publishing Ltd</pub><pmid>27028695</pmid><doi>10.1111/apa.13413</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta Paediatrica, 2016-08, Vol.105 (8), p.881-889 |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Amino acids Animals Blood Transfusion Erythrocytes - chemistry Female Fetal Growth Retardation - therapy Glucose Glucose - biosynthesis Insulin Insulin - metabolism Insulin Secretion Intrauterine growth restriction Liver - metabolism Metabolism Models, Animal Muscle, Skeletal - embryology Oxygen Oxygen - blood Pancreas - metabolism Placental Insufficiency - physiopathology Pregnancy Prenatal development Sheep |
| title | Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep |
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