Liquid Biopsy in Head and Neck Cancer: Promises and Challenges
Head and neck cancer is the sixth most common cancer worldwide. It remains one of the leading causes of death, and its early detection is crucial. Liquid biopsy has emerged as a promising tool for detecting and monitoring the disease status of patients with early and advanced cancers. Circulating tu...
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| Veröffentlicht in: | Journal of Dental Research 2018-06, Vol.97 (6), p.701-708 |
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| creator | Nonaka, T. Wong, D.T.W. |
| description | Head and neck cancer is the sixth most common cancer worldwide. It remains one of the leading causes of death, and its early detection is crucial. Liquid biopsy has emerged as a promising tool for detecting and monitoring the disease status of patients with early and advanced cancers. Circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomal miRNAs have received enormous attention because of their apparent clinical implications. Analyses of these circulating biomarkers have paved the way for novel therapeutic approaches and precision medicine. A growing number of reports have implicated the use of circulating biomarkers for detection, treatment planning, response monitoring, and prognosis assessment. Although these new biomarkers can provide a wide range of possible clinical applications, no validated circulating biomarkers have yet been integrated into clinical practice for head and neck cancer. In this review, we summarize the current knowledge of circulating biomarkers in this field, focusing on their feasibility, limitations, and key areas of clinical applications. We also highlight recent advances in salivary diagnostics and their potential application in head and neck cancer. |
| doi_str_mv | 10.1177/0022034518762071 |
| format | Article |
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It remains one of the leading causes of death, and its early detection is crucial. Liquid biopsy has emerged as a promising tool for detecting and monitoring the disease status of patients with early and advanced cancers. Circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomal miRNAs have received enormous attention because of their apparent clinical implications. Analyses of these circulating biomarkers have paved the way for novel therapeutic approaches and precision medicine. A growing number of reports have implicated the use of circulating biomarkers for detection, treatment planning, response monitoring, and prognosis assessment. Although these new biomarkers can provide a wide range of possible clinical applications, no validated circulating biomarkers have yet been integrated into clinical practice for head and neck cancer. In this review, we summarize the current knowledge of circulating biomarkers in this field, focusing on their feasibility, limitations, and key areas of clinical applications. 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It remains one of the leading causes of death, and its early detection is crucial. Liquid biopsy has emerged as a promising tool for detecting and monitoring the disease status of patients with early and advanced cancers. Circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomal miRNAs have received enormous attention because of their apparent clinical implications. Analyses of these circulating biomarkers have paved the way for novel therapeutic approaches and precision medicine. A growing number of reports have implicated the use of circulating biomarkers for detection, treatment planning, response monitoring, and prognosis assessment. Although these new biomarkers can provide a wide range of possible clinical applications, no validated circulating biomarkers have yet been integrated into clinical practice for head and neck cancer. In this review, we summarize the current knowledge of circulating biomarkers in this field, focusing on their feasibility, limitations, and key areas of clinical applications. We also highlight recent advances in salivary diagnostics and their potential application in head and neck cancer.</description><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy</subject><subject>Body fluids</subject><subject>Breast cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Neoplasm - analysis</subject><subject>Genomes</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Larynx</subject><subject>Liquid Biopsy - methods</subject><subject>Lung cancer</subject><subject>Mutation</subject><subject>Oral cancer</subject><subject>Patients</subject><subject>Plasma</subject><subject>Polymerase chain reaction</subject><subject>Precision medicine</subject><subject>Reviews</subject><subject>Saliva - chemistry</subject><subject>Therapeutic applications</subject><subject>Tumor cells</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtPwzAQhC0EgvK4c0KRuHAJ7NqOk3BAgoqXVAEHOFuOvW0DaVLsBqn_npTyrMRpD_Pt7I6GsX2EY8Q0PQHgHIRMMEsVhxTXWA8TKWNIclxnvYUcL_Qtth3CMwDmPBObbIvnCQqFWY-dDcrXtnTRRdlMwzwq6-iGjItM7aI7si9R39SW_Gn04JtJGSh8KP2xqSqqRxR22cbQVIH2PucOe7q6fOzfxIP769v--SC2UvFZnIsC0CBmhVTDvEidEZKscJDYBAwn51TqnMShQsjyQliBxhUOjCDpeApih50tfadtMSFnqZ55U-mpLyfGz3VjSv1XqcuxHjVvOskVZBnvDI4-DXzz2lKY6S6OpaoyNTVt0ByQI0qeqg49XEGfm9bXXTzNBYDqKJ50FCwp65sQPA2_n0HQi3L0ajndysHvEN8LX210QLwEghnRz9V_Dd8BCjeVAA</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Nonaka, T.</creator><creator>Wong, D.T.W.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9183-4734</orcidid></search><sort><creationdate>20180601</creationdate><title>Liquid Biopsy in Head and Neck Cancer: Promises and Challenges</title><author>Nonaka, T. ; Wong, D.T.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-93b01a118b46f9b7da34ec3d05c50a2edd67dd41f61089b3c31adbd0a3e4d2703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy</topic><topic>Body fluids</topic><topic>Breast cancer</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Neoplasm - analysis</topic><topic>Genomes</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Larynx</topic><topic>Liquid Biopsy - methods</topic><topic>Lung cancer</topic><topic>Mutation</topic><topic>Oral cancer</topic><topic>Patients</topic><topic>Plasma</topic><topic>Polymerase chain reaction</topic><topic>Precision medicine</topic><topic>Reviews</topic><topic>Saliva - chemistry</topic><topic>Therapeutic applications</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nonaka, T.</creatorcontrib><creatorcontrib>Wong, D.T.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Dental Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nonaka, T.</au><au>Wong, D.T.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liquid Biopsy in Head and Neck Cancer: Promises and Challenges</atitle><jtitle>Journal of Dental Research</jtitle><addtitle>J Dent Res</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>97</volume><issue>6</issue><spage>701</spage><epage>708</epage><pages>701-708</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><abstract>Head and neck cancer is the sixth most common cancer worldwide. It remains one of the leading causes of death, and its early detection is crucial. Liquid biopsy has emerged as a promising tool for detecting and monitoring the disease status of patients with early and advanced cancers. Circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomal miRNAs have received enormous attention because of their apparent clinical implications. Analyses of these circulating biomarkers have paved the way for novel therapeutic approaches and precision medicine. A growing number of reports have implicated the use of circulating biomarkers for detection, treatment planning, response monitoring, and prognosis assessment. Although these new biomarkers can provide a wide range of possible clinical applications, no validated circulating biomarkers have yet been integrated into clinical practice for head and neck cancer. 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| subjects | Biomarkers Biomarkers, Tumor - analysis Biopsy Body fluids Breast cancer Deoxyribonucleic acid DNA DNA, Neoplasm - analysis Genomes Head & neck cancer Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - pathology Human papillomavirus Humans Larynx Liquid Biopsy - methods Lung cancer Mutation Oral cancer Patients Plasma Polymerase chain reaction Precision medicine Reviews Saliva - chemistry Therapeutic applications Tumor cells |
| title | Liquid Biopsy in Head and Neck Cancer: Promises and Challenges |
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