Relationship Between Carbohydrate Antigen 125 and Coronary Artery Calcification in Patients without Known Coronary Artery Disease

Relationship Between Carbohydrate Antigen 125 and Coronary Artery Calcification in Patients without Known Coronary Artery Disease

BACKGROUND This study was designed to investigate the association between serum carbohydrate antigen 125 (CA125) and coronary artery calcification (CAC) score in patients without known coronary artery disease. MATERIAL AND METHODS The study groups included 348 consecutive subjects with chest pain bu...

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Veröffentlicht in:Medical science monitor 2018-05, Vol.24, p.2873-2877
Hauptverfasser: Fu, Kun, Liu, Hua-Dong, MaMuTi, KuerBanJiang, Hu, Dong-Nan, Hao, Peng
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container_title Medical science monitor
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creator Fu, Kun
Liu, Hua-Dong
MaMuTi, KuerBanJiang
Hu, Dong-Nan
Hao, Peng
description BACKGROUND This study was designed to investigate the association between serum carbohydrate antigen 125 (CA125) and coronary artery calcification (CAC) score in patients without known coronary artery disease. MATERIAL AND METHODS The study groups included 348 consecutive subjects with chest pain but without known coronary artery disease, and who underwent an estimation of CAC score in our hospital. RESULTS The clinical and laboratory characteristics of all subjects are presented according to serum CA125 concentrations tertiles. The CAC score was found to be increased in the tertiles (31.6 ±82.10, 73.3±125.6, 122.9±135.9 U/mL, p
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MATERIAL AND METHODS The study groups included 348 consecutive subjects with chest pain but without known coronary artery disease, and who underwent an estimation of CAC score in our hospital. RESULTS The clinical and laboratory characteristics of all subjects are presented according to serum CA125 concentrations tertiles. The CAC score was found to be increased in the tertiles (31.6 ±82.10, 73.3±125.6, 122.9±135.9 U/mL, p&lt;0.001). Serum CA125 concentrations are increased in calcium-positive patients compared with calcium-negative ones (9.3±4.79 vs. 11.2±7.36, p=0.003). A positive correlation between serum CA125 and CAC score was observed (r=0.319, p&lt;0.001) in all participants. Similarly, the serum concentrations of CA125 were found to be positively correlated with CAC score in both women and men (r=0.328, p&lt;0.001; r=0.265, p=0.001, respectively). Multiple linear regression analysis results indicated that serum CA125 concentrations are independently related to CAC score in the study population (beta=0.173, p=0.001), and age, sex, diabetes mellitus, and high-sensitivity C-reactive protein (hs-CRP) were also associated with CAC score in multiple linear regression analysis. CONCLUSIONS Serum CA125 concentrations are correlated with CAC score in the population without known coronary artery disease, and serum CA125 may be considered as a marker to estimate CAC in the study population.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.907418</identifier><identifier>PMID: 29731508</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Clinical Research</subject><ispartof>Medical science monitor, 2018-05, Vol.24, p.2873-2877</ispartof><rights>Med Sci Monit, 2018 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-8d1fd8918b0b9f06bd3b9f82940ff1ed49e123309e4085f17b1172f9fd7f39213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960219/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960219/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29731508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Kun</creatorcontrib><creatorcontrib>Liu, Hua-Dong</creatorcontrib><creatorcontrib>MaMuTi, KuerBanJiang</creatorcontrib><creatorcontrib>Hu, Dong-Nan</creatorcontrib><creatorcontrib>Hao, Peng</creatorcontrib><title>Relationship Between Carbohydrate Antigen 125 and Coronary Artery Calcification in Patients without Known Coronary Artery Disease</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>BACKGROUND This study was designed to investigate the association between serum carbohydrate antigen 125 (CA125) and coronary artery calcification (CAC) score in patients without known coronary artery disease. MATERIAL AND METHODS The study groups included 348 consecutive subjects with chest pain but without known coronary artery disease, and who underwent an estimation of CAC score in our hospital. RESULTS The clinical and laboratory characteristics of all subjects are presented according to serum CA125 concentrations tertiles. The CAC score was found to be increased in the tertiles (31.6 ±82.10, 73.3±125.6, 122.9±135.9 U/mL, p&lt;0.001). Serum CA125 concentrations are increased in calcium-positive patients compared with calcium-negative ones (9.3±4.79 vs. 11.2±7.36, p=0.003). A positive correlation between serum CA125 and CAC score was observed (r=0.319, p&lt;0.001) in all participants. Similarly, the serum concentrations of CA125 were found to be positively correlated with CAC score in both women and men (r=0.328, p&lt;0.001; r=0.265, p=0.001, respectively). Multiple linear regression analysis results indicated that serum CA125 concentrations are independently related to CAC score in the study population (beta=0.173, p=0.001), and age, sex, diabetes mellitus, and high-sensitivity C-reactive protein (hs-CRP) were also associated with CAC score in multiple linear regression analysis. CONCLUSIONS Serum CA125 concentrations are correlated with CAC score in the population without known coronary artery disease, and serum CA125 may be considered as a marker to estimate CAC in the study population.</description><subject>Clinical Research</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNplUU1PVDEUbYhGEF25N12akIHe9n20G5PhIUqEaFTWTd97t0zNm3ZoO0xY8s9pGCAYV-fk3nPPPckh5AOwQ-BNrY4ufl8cKtZWIHfIHjSVmIm2Zq9e8F3yNqW_jHHZsPoN2eWqFVAzuUfufuFksgs-LdyKHmPeIHramdiHxe0YTUY699ldlSHwmho_0i7E4E28pfOYsUBnpsFZNzzYUOfpz8LQ50Q3Li_COtPvPmz8f3cnLqFJ-I68tmZK-P4R98nl6Zc_3bfZ-Y-vZ938fDYICXkmR7CjVCB71ivLmn4UBSVXFbMWcKwUAheCKayYrC20PUDLrbJja4XiIPbJ563vat0vcRxKwmgmvYpuWULpYJz-d-PdQl-FG12rhnFQxeDTo0EM12tMWS9dGnCajMewTpozUbesLWmL9GArHWJIKaJ9fgNMP5SmS2l6W1pRf3yZ7Fn71JK4Bx_vlK4</recordid><startdate>20180507</startdate><enddate>20180507</enddate><creator>Fu, Kun</creator><creator>Liu, Hua-Dong</creator><creator>MaMuTi, KuerBanJiang</creator><creator>Hu, Dong-Nan</creator><creator>Hao, Peng</creator><general>International Scientific Literature, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180507</creationdate><title>Relationship Between Carbohydrate Antigen 125 and Coronary Artery Calcification in Patients without Known Coronary Artery Disease</title><author>Fu, Kun ; Liu, Hua-Dong ; MaMuTi, KuerBanJiang ; Hu, Dong-Nan ; Hao, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-8d1fd8918b0b9f06bd3b9f82940ff1ed49e123309e4085f17b1172f9fd7f39213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Clinical Research</topic><toplevel>online_resources</toplevel><creatorcontrib>Fu, Kun</creatorcontrib><creatorcontrib>Liu, Hua-Dong</creatorcontrib><creatorcontrib>MaMuTi, KuerBanJiang</creatorcontrib><creatorcontrib>Hu, Dong-Nan</creatorcontrib><creatorcontrib>Hao, Peng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Kun</au><au>Liu, Hua-Dong</au><au>MaMuTi, KuerBanJiang</au><au>Hu, Dong-Nan</au><au>Hao, Peng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Carbohydrate Antigen 125 and Coronary Artery Calcification in Patients without Known Coronary Artery Disease</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2018-05-07</date><risdate>2018</risdate><volume>24</volume><spage>2873</spage><epage>2877</epage><pages>2873-2877</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>BACKGROUND This study was designed to investigate the association between serum carbohydrate antigen 125 (CA125) and coronary artery calcification (CAC) score in patients without known coronary artery disease. MATERIAL AND METHODS The study groups included 348 consecutive subjects with chest pain but without known coronary artery disease, and who underwent an estimation of CAC score in our hospital. RESULTS The clinical and laboratory characteristics of all subjects are presented according to serum CA125 concentrations tertiles. The CAC score was found to be increased in the tertiles (31.6 ±82.10, 73.3±125.6, 122.9±135.9 U/mL, p&lt;0.001). Serum CA125 concentrations are increased in calcium-positive patients compared with calcium-negative ones (9.3±4.79 vs. 11.2±7.36, p=0.003). A positive correlation between serum CA125 and CAC score was observed (r=0.319, p&lt;0.001) in all participants. Similarly, the serum concentrations of CA125 were found to be positively correlated with CAC score in both women and men (r=0.328, p&lt;0.001; r=0.265, p=0.001, respectively). Multiple linear regression analysis results indicated that serum CA125 concentrations are independently related to CAC score in the study population (beta=0.173, p=0.001), and age, sex, diabetes mellitus, and high-sensitivity C-reactive protein (hs-CRP) were also associated with CAC score in multiple linear regression analysis. CONCLUSIONS Serum CA125 concentrations are correlated with CAC score in the population without known coronary artery disease, and serum CA125 may be considered as a marker to estimate CAC in the study population.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>29731508</pmid><doi>10.12659/MSM.907418</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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title Relationship Between Carbohydrate Antigen 125 and Coronary Artery Calcification in Patients without Known Coronary Artery Disease
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