Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis

Purpose This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind–body exercises on symptoms and quality of life (QOL) in cancer survivors. Methods A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluat...

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Veröffentlicht in:Journal of cancer survivorship 2018-04, Vol.12 (2), p.256-267
Hauptverfasser: Wayne, Peter M., Lee, M.S., Novakowski, J., Osypiuk, K., Ligibel, J., Carlson, L.E., Song, R.
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container_end_page 267
container_issue 2
container_start_page 256
container_title Journal of cancer survivorship
container_volume 12
creator Wayne, Peter M.
Lee, M.S.
Novakowski, J.
Osypiuk, K.
Ligibel, J.
Carlson, L.E.
Song, R.
description Purpose This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind–body exercises on symptoms and quality of life (QOL) in cancer survivors. Methods A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges’ g ) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed. Results Our search identified 22 studies, including 15 RCTs that evaluated 1283 participants in total, 75% women. RCTs evaluated breast ( n  = 7), prostate ( n  = 2), lymphoma ( n  = 1), lung (n = 1), or combined ( n  = 4) cancers. RCT comparison groups included active intervention ( n  = 7), usual care ( n  = 5), or both ( n  = 3). Duration of TCQ training ranged from 3 to 12 weeks. Methodological bias was low in 12 studies and high in 3 studies. TCQ was associated with significant improvement in fatigue (ES = − 0.53, p  
doi_str_mv 10.1007/s11764-017-0665-5
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Methods A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges’ g ) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed. Results Our search identified 22 studies, including 15 RCTs that evaluated 1283 participants in total, 75% women. RCTs evaluated breast ( n  = 7), prostate ( n  = 2), lymphoma ( n  = 1), lung (n = 1), or combined ( n  = 4) cancers. RCT comparison groups included active intervention ( n  = 7), usual care ( n  = 5), or both ( n  = 3). Duration of TCQ training ranged from 3 to 12 weeks. Methodological bias was low in 12 studies and high in 3 studies. TCQ was associated with significant improvement in fatigue (ES = − 0.53, p  &lt; 0.001), sleep difficulty (ES = − 0.49, p  = 0.018), depression (ES = − 0.27, p  = 0.001), and overall QOL (ES = 0.33, p  = 0.004); a statistically non-significant trend was observed for pain (ES = − 0.38, p  = 0.136). Random effects models were used for meta-analysis based on Q test and I 2 criteria. Funnel plots suggest some degree of publication bias. Findings in non-randomized studies largely paralleled meta-analysis results. Conclusions Larger and methodologically sound trials with longer follow-up periods and appropriate comparison groups are needed before definitive conclusions can be drawn, and cancer- and symptom-specific recommendations can be made. Implications for Cancer Survivors TCQ shows promise in addressing cancer-related symptoms and QOL in cancer survivors.</description><identifier>ISSN: 1932-2259</identifier><identifier>EISSN: 1932-2267</identifier><identifier>DOI: 10.1007/s11764-017-0665-5</identifier><identifier>PMID: 29222705</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject><![CDATA[Bias ; Breast cancer ; Cancer ; Cancer Survivors - psychology ; Cancer Survivors - statistics & numerical data ; Clinical trials ; Databases, Factual ; Depression - epidemiology ; Depression - etiology ; Depression - therapy ; Exercise - physiology ; Exercise - psychology ; Exercise Therapy - methods ; Exercise Therapy - psychology ; Exercise Therapy - statistics & numerical data ; Fatigue ; Fatigue - epidemiology ; Fatigue - etiology ; Fatigue - therapy ; Female ; Health Informatics ; Health Promotion and Disease Prevention ; Humans ; Lung cancer ; Lungs ; Lymphoma ; Male ; Martial arts ; Medicine ; Medicine & Public Health ; Mental depression ; Meta-analysis ; Neoplasms - epidemiology ; Neoplasms - psychology ; Neoplasms - rehabilitation ; Oncology ; Pain ; Primary Care Medicine ; Prostate ; Public Health ; Qigong - psychology ; Qigong - statistics & numerical data ; Quality of Life ; Quality of Life Research ; Randomization ; Randomized Controlled Trials as Topic - statistics & numerical data ; Respiratory therapy ; Review ; Sleep ; Statistical analysis ; Studies ; Systematic review ; Tai Ji - psychology ; Tai Ji - statistics & numerical data]]></subject><ispartof>Journal of cancer survivorship, 2018-04, Vol.12 (2), p.256-267</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2017</rights><rights>Journal of Cancer Survivorship is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1b0d7dc9d3576c810aa0787f2b5b5ddb6ecb97d082416617f0e8d656c9b4e5a33</citedby><cites>FETCH-LOGICAL-c470t-1b0d7dc9d3576c810aa0787f2b5b5ddb6ecb97d082416617f0e8d656c9b4e5a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11764-017-0665-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11764-017-0665-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29222705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wayne, Peter M.</creatorcontrib><creatorcontrib>Lee, M.S.</creatorcontrib><creatorcontrib>Novakowski, J.</creatorcontrib><creatorcontrib>Osypiuk, K.</creatorcontrib><creatorcontrib>Ligibel, J.</creatorcontrib><creatorcontrib>Carlson, L.E.</creatorcontrib><creatorcontrib>Song, R.</creatorcontrib><title>Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis</title><title>Journal of cancer survivorship</title><addtitle>J Cancer Surviv</addtitle><addtitle>J Cancer Surviv</addtitle><description>Purpose This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind–body exercises on symptoms and quality of life (QOL) in cancer survivors. Methods A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges’ g ) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed. Results Our search identified 22 studies, including 15 RCTs that evaluated 1283 participants in total, 75% women. RCTs evaluated breast ( n  = 7), prostate ( n  = 2), lymphoma ( n  = 1), lung (n = 1), or combined ( n  = 4) cancers. RCT comparison groups included active intervention ( n  = 7), usual care ( n  = 5), or both ( n  = 3). Duration of TCQ training ranged from 3 to 12 weeks. Methodological bias was low in 12 studies and high in 3 studies. TCQ was associated with significant improvement in fatigue (ES = − 0.53, p  &lt; 0.001), sleep difficulty (ES = − 0.49, p  = 0.018), depression (ES = − 0.27, p  = 0.001), and overall QOL (ES = 0.33, p  = 0.004); a statistically non-significant trend was observed for pain (ES = − 0.38, p  = 0.136). Random effects models were used for meta-analysis based on Q test and I 2 criteria. Funnel plots suggest some degree of publication bias. Findings in non-randomized studies largely paralleled meta-analysis results. Conclusions Larger and methodologically sound trials with longer follow-up periods and appropriate comparison groups are needed before definitive conclusions can be drawn, and cancer- and symptom-specific recommendations can be made. Implications for Cancer Survivors TCQ shows promise in addressing cancer-related symptoms and QOL in cancer survivors.</description><subject>Bias</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer Survivors - psychology</subject><subject>Cancer Survivors - statistics &amp; numerical data</subject><subject>Clinical trials</subject><subject>Databases, Factual</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Depression - therapy</subject><subject>Exercise - physiology</subject><subject>Exercise - psychology</subject><subject>Exercise Therapy - methods</subject><subject>Exercise Therapy - psychology</subject><subject>Exercise Therapy - statistics &amp; numerical data</subject><subject>Fatigue</subject><subject>Fatigue - epidemiology</subject><subject>Fatigue - etiology</subject><subject>Fatigue - therapy</subject><subject>Female</subject><subject>Health Informatics</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lungs</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Martial arts</subject><subject>Medicine</subject><subject>Medicine &amp; 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Methods A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges’ g ) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed. Results Our search identified 22 studies, including 15 RCTs that evaluated 1283 participants in total, 75% women. RCTs evaluated breast ( n  = 7), prostate ( n  = 2), lymphoma ( n  = 1), lung (n = 1), or combined ( n  = 4) cancers. RCT comparison groups included active intervention ( n  = 7), usual care ( n  = 5), or both ( n  = 3). Duration of TCQ training ranged from 3 to 12 weeks. Methodological bias was low in 12 studies and high in 3 studies. TCQ was associated with significant improvement in fatigue (ES = − 0.53, p  &lt; 0.001), sleep difficulty (ES = − 0.49, p  = 0.018), depression (ES = − 0.27, p  = 0.001), and overall QOL (ES = 0.33, p  = 0.004); a statistically non-significant trend was observed for pain (ES = − 0.38, p  = 0.136). Random effects models were used for meta-analysis based on Q test and I 2 criteria. Funnel plots suggest some degree of publication bias. Findings in non-randomized studies largely paralleled meta-analysis results. Conclusions Larger and methodologically sound trials with longer follow-up periods and appropriate comparison groups are needed before definitive conclusions can be drawn, and cancer- and symptom-specific recommendations can be made. Implications for Cancer Survivors TCQ shows promise in addressing cancer-related symptoms and QOL in cancer survivors.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29222705</pmid><doi>10.1007/s11764-017-0665-5</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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subjects Bias
Breast cancer
Cancer
Cancer Survivors - psychology
Cancer Survivors - statistics & numerical data
Clinical trials
Databases, Factual
Depression - epidemiology
Depression - etiology
Depression - therapy
Exercise - physiology
Exercise - psychology
Exercise Therapy - methods
Exercise Therapy - psychology
Exercise Therapy - statistics & numerical data
Fatigue
Fatigue - epidemiology
Fatigue - etiology
Fatigue - therapy
Female
Health Informatics
Health Promotion and Disease Prevention
Humans
Lung cancer
Lungs
Lymphoma
Male
Martial arts
Medicine
Medicine & Public Health
Mental depression
Meta-analysis
Neoplasms - epidemiology
Neoplasms - psychology
Neoplasms - rehabilitation
Oncology
Pain
Primary Care Medicine
Prostate
Public Health
Qigong - psychology
Qigong - statistics & numerical data
Quality of Life
Quality of Life Research
Randomization
Randomized Controlled Trials as Topic - statistics & numerical data
Respiratory therapy
Review
Sleep
Statistical analysis
Studies
Systematic review
Tai Ji - psychology
Tai Ji - statistics & numerical data
title Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis
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