IgG-single-chain TRAIL fusion proteins for tumour therapy

Single-chain formats of TNF-related apoptosis inducing ligand (scTRAIL) can serve as effector components of tumour-associated antigen-targeted as well as non-targeted fusion proteins, being characterized by high tumour cell-specific induction of apoptosis through death receptor activation. We studie...

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Veröffentlicht in:	Scientific reports 2018-05, Vol.8 (1), p.7808-11, Article 7808
Hauptverfasser:	Siegemund, Martin, Schneider, Felix, Hutt, Meike, Seifert, Oliver, Müller, Ines, Kulms, Dagmar, Pfizenmaier, Klaus, Kontermann, Roland E.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 631/61/2297 631/61/338/469 631/67/1059/602 64/60 82 82/1 82/16 82/80 82/83 Antibodies, Monoclonal, Humanized - pharmacology Antigens Antineoplastic Agents - pharmacology Apoptosis Biological activity Bortezomib C-Terminus Cancer Cell Death - drug effects Cell Line, Tumor Death receptors DIABLO protein Epidermal growth factor receptors ErbB Receptors - immunology Humanities and Social Sciences Humans Immunoglobulin G Immunoglobulin G - chemistry Immunoglobulin G - pharmacology Immunoglobulins multidisciplinary Proteins Receptor mechanisms Recombinant Fusion Proteins - pharmacology Science Science (multidisciplinary) Synergism TNF-Related Apoptosis-Inducing Ligand - chemistry TNF-Related Apoptosis-Inducing Ligand - pharmacology TRAIL protein Tumor cell lines Tumor necrosis factor Tumors Xenografts
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