Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging

MALDI mass-spectrometry imaging (MALDI-MSI) is a technique capable of the label-free identification and visualization of analytes in tissue sections. We have previously applied MALDI-MSI to the study of the spatial distribution of tuberculosis (TB) drugs in necrotic lung granulomas characteristic of...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-05, Vol.90 (10), p.6275-6282
Hauptverfasser:	Blanc, Landry, Lenaerts, Anne, Dartois, Véronique, Prideaux, Brendan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animal models Animals Antitubercular Agents - analysis Antitubercular Agents - pharmacology Bacteria Bioengineering Biomarkers Biomarkers - analysis Chemistry Drugs Female Glycolipids Granuloma Imaging Lesions Life Sciences Lung diseases Medical imaging Metabolites Mice Mice, Inbred BALB C Mice, Inbred C3H Microscopy Mycobacterium tuberculosis - chemistry Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Pathogenesis Prescription drugs Rabbits Spatial distribution Spatial resolution Spectrometry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Staining Tissues Tuberculosis Tuberculosis - drug therapy Tuberculosis - pathology Visualization
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