The effect of thiamine and its metabolites on peripheral neuropathic pain induced by cisplatin in rats

Thiamine pyrophosphate (TPP) is the active metabolite of thiamine. This study aimed to investigate the effects of thiamine and TPP on cisplatin-induced peripheral neuropathic pain (PNP). Male albino Wistar type Rattus norvegicus were divided into six groups (n=6) that received 2 mg/kg cisplatin (CIS...

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Veröffentlicht in:	Experimental Animals 2018, Vol.67(2), pp.259-269
Hauptverfasser:	Onk, Didem, Mammadov, Renad, Suleyman, Bahadir, Cimen, Ferda Keskin, Cankaya, Murat, Gul, Vahdet, Altuner, Durdu, Senol, Onur, Kadioglu, Yucel, Malkoc, Ismail, Suleyman, Halis
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - administration & dosage Analgesics - metabolism Animals Cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects Cisplatin - antagonists & inhibitors Disease Models, Animal Distilled water Glutathione IL-1β Interleukin-1beta - metabolism Male Malondialdehyde Malondialdehyde - metabolism Metabolites Nerves Neuralgia - chemically induced Neuralgia - drug therapy Neuralgia - pathology Original Pain Pain perception Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - pathology Peripheral neuropathy rat Rats, Wistar Sciatic nerve Sciatic Nerve - pathology Thiamine Thiamine - administration & dosage Thiamine - metabolism Thiamine - pharmacology Thiamine Pyrophosphate - administration & dosage Thiamine Pyrophosphate - metabolism Thiamine Pyrophosphate - pharmacology Vitamin B
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