Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes, including those involved in B-cell maturation, d...
Gespeichert in:
| Veröffentlicht in: | Oncotarget 2018-05, Vol.9 (33), p.22907-22914 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 22914 |
|---|---|
| container_issue | 33 |
| container_start_page | 22907 |
| container_title | Oncotarget |
| container_volume | 9 |
| creator | Gutierrez-Camino, Angela Martin-Guerrero, Idoia Dolzan, Vita Jazbec, Janez Carbone-Bañeres, Ana Garcia de Andoin, Nagore Sastre, Ana Astigarraga, Itziar Navajas, Aurora Garcia-Orad, Africa |
| description | Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes, including those involved in B-cell maturation, differentiation and proliferation. Genetic variants in miRNAs can alter their own levels or function, affecting their target gene expression, and then, may affect ALL risk. Therefore, the aim of this study was to determine the role of miRNA genetic variants in B-ALL susceptibility. We analyzed all variants in pre-miRNAs (MAF > 1%) in two independent cohorts from Spain and Slovenia and inferred their functional effect by
analysis. SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway. These SNPs could be novel markers for ALL susceptibility. |
| doi_str_mv | 10.18632/oncotarget.25144 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5955428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2045271677</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3144-d2c69b462e0ac8bef4ce249d1133f3ce7a6cd687342297b943e0bfb1e94ef10e3</originalsourceid><addsrcrecordid>eNpVUclOwzAQtRAIqtIP4IJ85JISL3HiCxKqWCpVgFiOyHKcSWtw4hInlfr3hLZsc5kZvZk3b_QQOiHxmGSC0XNfG9_qZg7tmCaE8z00IJLLiCYJ2_9TH6FRCG9xHwlPMyoP0RGVqRREkAF6ndYr71ZQQd1iX-Knu4eAbY0r-xgxQlKs62LbiEwW9AsyC-uKhfcF1qZrAbt1tVz43OnQWoMddO9QWY0bG96P0UGpXYDRLg_Ry_XV8-Q2mt3fTCeXs8iwXnhUUCNkzgWFWJssh5IboFwWhDBWMgOpFqYQWco47ZXnkjOI8zInIDmUJAY2RBdb3mWXV1CY_plGO7VsbKWbtfLaqv9IbRdq7lcqkUnCadYTnO0IGv_RQWhVZYMB53QNvguKxjyhKRFp2o-S7ahpfAgNlD9nSKw2zqhfZ9TGmX7n9K--n41vH9gn9TKMrQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2045271677</pqid></control><display><type>article</type><title>Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><source>Free E- Journals</source><creator>Gutierrez-Camino, Angela ; Martin-Guerrero, Idoia ; Dolzan, Vita ; Jazbec, Janez ; Carbone-Bañeres, Ana ; Garcia de Andoin, Nagore ; Sastre, Ana ; Astigarraga, Itziar ; Navajas, Aurora ; Garcia-Orad, Africa</creator><creatorcontrib>Gutierrez-Camino, Angela ; Martin-Guerrero, Idoia ; Dolzan, Vita ; Jazbec, Janez ; Carbone-Bañeres, Ana ; Garcia de Andoin, Nagore ; Sastre, Ana ; Astigarraga, Itziar ; Navajas, Aurora ; Garcia-Orad, Africa</creatorcontrib><description>Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes, including those involved in B-cell maturation, differentiation and proliferation. Genetic variants in miRNAs can alter their own levels or function, affecting their target gene expression, and then, may affect ALL risk. Therefore, the aim of this study was to determine the role of miRNA genetic variants in B-ALL susceptibility. We analyzed all variants in pre-miRNAs (MAF > 1%) in two independent cohorts from Spain and Slovenia and inferred their functional effect by
analysis. SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway. These SNPs could be novel markers for ALL susceptibility.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.25144</identifier><identifier>PMID: 29796161</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Research Paper</subject><ispartof>Oncotarget, 2018-05, Vol.9 (33), p.22907-22914</ispartof><rights>Copyright: © 2018 Gutierrez-Camino et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3144-d2c69b462e0ac8bef4ce249d1133f3ce7a6cd687342297b943e0bfb1e94ef10e3</citedby><cites>FETCH-LOGICAL-c3144-d2c69b462e0ac8bef4ce249d1133f3ce7a6cd687342297b943e0bfb1e94ef10e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955428/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955428/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29796161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gutierrez-Camino, Angela</creatorcontrib><creatorcontrib>Martin-Guerrero, Idoia</creatorcontrib><creatorcontrib>Dolzan, Vita</creatorcontrib><creatorcontrib>Jazbec, Janez</creatorcontrib><creatorcontrib>Carbone-Bañeres, Ana</creatorcontrib><creatorcontrib>Garcia de Andoin, Nagore</creatorcontrib><creatorcontrib>Sastre, Ana</creatorcontrib><creatorcontrib>Astigarraga, Itziar</creatorcontrib><creatorcontrib>Navajas, Aurora</creatorcontrib><creatorcontrib>Garcia-Orad, Africa</creatorcontrib><title>Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes, including those involved in B-cell maturation, differentiation and proliferation. Genetic variants in miRNAs can alter their own levels or function, affecting their target gene expression, and then, may affect ALL risk. Therefore, the aim of this study was to determine the role of miRNA genetic variants in B-ALL susceptibility. We analyzed all variants in pre-miRNAs (MAF > 1%) in two independent cohorts from Spain and Slovenia and inferred their functional effect by
analysis. SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway. These SNPs could be novel markers for ALL susceptibility.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVUclOwzAQtRAIqtIP4IJ85JISL3HiCxKqWCpVgFiOyHKcSWtw4hInlfr3hLZsc5kZvZk3b_QQOiHxmGSC0XNfG9_qZg7tmCaE8z00IJLLiCYJ2_9TH6FRCG9xHwlPMyoP0RGVqRREkAF6ndYr71ZQQd1iX-Knu4eAbY0r-xgxQlKs62LbiEwW9AsyC-uKhfcF1qZrAbt1tVz43OnQWoMddO9QWY0bG96P0UGpXYDRLg_Ry_XV8-Q2mt3fTCeXs8iwXnhUUCNkzgWFWJssh5IboFwWhDBWMgOpFqYQWco47ZXnkjOI8zInIDmUJAY2RBdb3mWXV1CY_plGO7VsbKWbtfLaqv9IbRdq7lcqkUnCadYTnO0IGv_RQWhVZYMB53QNvguKxjyhKRFp2o-S7ahpfAgNlD9nSKw2zqhfZ9TGmX7n9K--n41vH9gn9TKMrQ</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Gutierrez-Camino, Angela</creator><creator>Martin-Guerrero, Idoia</creator><creator>Dolzan, Vita</creator><creator>Jazbec, Janez</creator><creator>Carbone-Bañeres, Ana</creator><creator>Garcia de Andoin, Nagore</creator><creator>Sastre, Ana</creator><creator>Astigarraga, Itziar</creator><creator>Navajas, Aurora</creator><creator>Garcia-Orad, Africa</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180501</creationdate><title>Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk</title><author>Gutierrez-Camino, Angela ; Martin-Guerrero, Idoia ; Dolzan, Vita ; Jazbec, Janez ; Carbone-Bañeres, Ana ; Garcia de Andoin, Nagore ; Sastre, Ana ; Astigarraga, Itziar ; Navajas, Aurora ; Garcia-Orad, Africa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3144-d2c69b462e0ac8bef4ce249d1133f3ce7a6cd687342297b943e0bfb1e94ef10e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Gutierrez-Camino, Angela</creatorcontrib><creatorcontrib>Martin-Guerrero, Idoia</creatorcontrib><creatorcontrib>Dolzan, Vita</creatorcontrib><creatorcontrib>Jazbec, Janez</creatorcontrib><creatorcontrib>Carbone-Bañeres, Ana</creatorcontrib><creatorcontrib>Garcia de Andoin, Nagore</creatorcontrib><creatorcontrib>Sastre, Ana</creatorcontrib><creatorcontrib>Astigarraga, Itziar</creatorcontrib><creatorcontrib>Navajas, Aurora</creatorcontrib><creatorcontrib>Garcia-Orad, Africa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gutierrez-Camino, Angela</au><au>Martin-Guerrero, Idoia</au><au>Dolzan, Vita</au><au>Jazbec, Janez</au><au>Carbone-Bañeres, Ana</au><au>Garcia de Andoin, Nagore</au><au>Sastre, Ana</au><au>Astigarraga, Itziar</au><au>Navajas, Aurora</au><au>Garcia-Orad, Africa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>9</volume><issue>33</issue><spage>22907</spage><epage>22914</epage><pages>22907-22914</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes, including those involved in B-cell maturation, differentiation and proliferation. Genetic variants in miRNAs can alter their own levels or function, affecting their target gene expression, and then, may affect ALL risk. Therefore, the aim of this study was to determine the role of miRNA genetic variants in B-ALL susceptibility. We analyzed all variants in pre-miRNAs (MAF > 1%) in two independent cohorts from Spain and Slovenia and inferred their functional effect by
analysis. SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway. These SNPs could be novel markers for ALL susceptibility.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>29796161</pmid><doi>10.18632/oncotarget.25144</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1949-2553 |
| ispartof | Oncotarget, 2018-05, Vol.9 (33), p.22907-22914 |
| issn | 1949-2553 1949-2553 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5955428 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central; Free E- Journals |
| subjects | Research Paper |
| title | Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T10%3A03%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Involvement%20of%20SNPs%20in%20miR-3117%20and%20miR-3689d2%20in%20childhood%20acute%20lymphoblastic%20leukemia%20risk&rft.jtitle=Oncotarget&rft.au=Gutierrez-Camino,%20Angela&rft.date=2018-05-01&rft.volume=9&rft.issue=33&rft.spage=22907&rft.epage=22914&rft.pages=22907-22914&rft.issn=1949-2553&rft.eissn=1949-2553&rft_id=info:doi/10.18632/oncotarget.25144&rft_dat=%3Cproquest_pubme%3E2045271677%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2045271677&rft_id=info:pmid/29796161&rfr_iscdi=true |