Regulatory Role of Circular RNAs and Neurological Disorders
Circular RNAs (circRNAs) are a class of long noncoding RNAs that are characterized by the presence of covalently linked ends and have been found in all life kingdoms. Exciting studies in regulatory roles of circRNAs are emerging. Here, we summarize classification, characteristics, biogenesis, and re...
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| Veröffentlicht in: | Molecular neurobiology 2017-09, Vol.54 (7), p.5156-5165 |
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| container_title | Molecular neurobiology |
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| creator | Floris, Gabriele Zhang, Longbin Follesa, Paolo Sun, Tao |
| description | Circular RNAs (circRNAs) are a class of long noncoding RNAs that are characterized by the presence of covalently linked ends and have been found in all life kingdoms. Exciting studies in regulatory roles of circRNAs are emerging. Here, we summarize classification, characteristics, biogenesis, and regulatory functions of circRNAs. CircRNAs are found to be preferentially expressed along neural genes and in neural tissues. We thus highlight the association of circRNA dysregulation with neurodegenerative diseases such as Alzheimer’s disease. Investigation of regulatory role of circRNAs will shed novel light in gene expression mechanisms during development and under disease conditions and may identify circRNAs as new biomarkers for aging and neurodegenerative disorders. |
| doi_str_mv | 10.1007/s12035-016-0055-4 |
| format | Article |
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Investigation of regulatory role of circRNAs will shed novel light in gene expression mechanisms during development and under disease conditions and may identify circRNAs as new biomarkers for aging and neurodegenerative disorders.</description><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Biomarkers - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Classification</subject><subject>Covalence</subject><subject>Gene expression</subject><subject>Gene Expression - genetics</subject><subject>Humans</subject><subject>Nervous System Diseases - genetics</subject><subject>Neurobiology</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>Neurological disorders</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA - genetics</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Tissues</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kd9LHDEQx4NY9LT-Ab7Igi99WZuZZHazCAU5f7QgFo72OeSys-fK3sYmtwX_-0ZOxRb6NJD5zGcyfIU4BnkGUtafE6BUVEqoSimJSr0jZkDUlAAGd8VMmkaVdaXNvjhI6UFKRJD1ntjHmsigMjNxvuDVNLhNiE_FIgxchK6Y99Hnt1gs7i5S4ca2uOMphiGseu-G4rJPIbYc00fxoXND4qOXeih-Xl_9mH8tb7_ffJtf3JaeVLUp2bVVp0wLreeuNuQQtUZmg9CSBvS60UgGmB3BUqslLj2RA_C6Qm6lOhRftt7HabnmbBk30Q32MfZrF59scL39uzP293YVfltqiFQDWfDpRRDDr4nTxq775HkY3MhhShYMNTXWCkxGT_9BH8IUx3yehQZVo0jWKlOwpXwMKUXu3j4D0j5HY7fR2ByNfY7G6jxz8v6Kt4nXLDKAWyDl1rji-G71f61_AO-fmK8</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Floris, Gabriele</creator><creator>Zhang, Longbin</creator><creator>Follesa, Paolo</creator><creator>Sun, Tao</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Regulatory Role of Circular RNAs and Neurological Disorders</title><author>Floris, Gabriele ; Zhang, Longbin ; Follesa, Paolo ; Sun, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-ead6f38d1dcef785a22442ee821d5412c4942581eea51b43b2bc55a11c462ed03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Biomarkers - analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Classification</topic><topic>Covalence</topic><topic>Gene expression</topic><topic>Gene Expression - genetics</topic><topic>Humans</topic><topic>Nervous System Diseases - genetics</topic><topic>Neurobiology</topic><topic>Neurodegenerative diseases</topic><topic>Neurological diseases</topic><topic>Neurological disorders</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA - genetics</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Floris, Gabriele</creatorcontrib><creatorcontrib>Zhang, Longbin</creatorcontrib><creatorcontrib>Follesa, Paolo</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Floris, Gabriele</au><au>Zhang, Longbin</au><au>Follesa, Paolo</au><au>Sun, Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulatory Role of Circular RNAs and Neurological Disorders</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>54</volume><issue>7</issue><spage>5156</spage><epage>5165</epage><pages>5156-5165</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Circular RNAs (circRNAs) are a class of long noncoding RNAs that are characterized by the presence of covalently linked ends and have been found in all life kingdoms. 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| subjects | Alzheimer Disease - genetics Alzheimer's disease Animals Biomarkers - analysis Biomedical and Life Sciences Biomedicine Cell Biology Classification Covalence Gene expression Gene Expression - genetics Humans Nervous System Diseases - genetics Neurobiology Neurodegenerative diseases Neurological diseases Neurological disorders Neurology Neurosciences Ribonucleic acid RNA RNA - genetics RNA, Long Noncoding - genetics Tissues |
| title | Regulatory Role of Circular RNAs and Neurological Disorders |
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