Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte

Single-cell transcriptomics analyses of cell intermediates during the reprogramming from fibroblast to cardiomyocyte were used to reconstruct the reprogramming trajectory and to uncover intermediate cell populations, gene pathways and regulators involved in this process. Fibroblast splicing factor T...

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Veröffentlicht in:	Nature (London) 2017-11, Vol.551 (7678), p.100-104
Hauptverfasser:	Liu, Ziqing, Wang, Li, Welch, Joshua D., Ma, Hong, Zhou, Yang, Vaseghi, Haley Ruth, Yu, Shuo, Wall, Joseph Blake, Alimohamadi, Sahar, Zheng, Michael, Yin, Chaoying, Shen, Weining, Prins, Jan F., Liu, Jiandong, Qian, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/106 13/31 13/44 13/62 13/89 45/43 45/61 45/91 631/136/2128 631/532/2435 Algorithms Animals Cardiomyocytes Cell cycle Cell growth Cell Lineage - genetics Cell proliferation Cellular Reprogramming - genetics Clustering Conversion Down-Regulation - genetics Experiments Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Functional analysis GATA4 Transcription Factor - genetics Gene expression Gene sequencing Genetic aspects Heart cells Heart diseases Heterogeneity Heterogeneous-Nuclear Ribonucleoproteins - deficiency Heterogeneous-Nuclear Ribonucleoproteins - genetics Heterogeneous-Nuclear Ribonucleoproteins - metabolism Humanities and Social Sciences letter MEF2 Transcription Factors - genetics Mice mRNA processing multidisciplinary Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Observations Polypyrimidine Tract-Binding Protein - deficiency Polypyrimidine Tract-Binding Protein - genetics Polypyrimidine Tract-Binding Protein - metabolism Principal components analysis Quantitative analysis Regeneration Regulators Ribonucleic acid RNA RNA Splicing - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Science Single-Cell Analysis Splicing Splicing factors Subpopulations Surface markers T-Box Domain Proteins - genetics Tissue engineering Transcription (Genetics) Transcriptome
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