Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease

Kawasaki disease (KD), which is the leading cause of pediatric heart disease, is characterized by coronary vasculitis and subsequent aneurysm formation. Although intravenous immunoglobulin therapy is effective for reducing aneurysm formation, a certain number of patients are resistant to this therap...

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Veröffentlicht in:	Scientific reports 2018-05, Vol.8 (1), p.7601-13, Article 7601
Hauptverfasser:	Nakamura, Jun, Watanabe, Sachiko, Kimura, Hiroaki, Kobayashi, Motoi, Karasawa, Tadayoshi, Kamata, Ryo, Usui-Kawanishi, Fumitake, Sadatomo, Ai, Mizukami, Hiroaki, Nagi-Miura, Noriko, Ohno, Naohito, Kasahara, Tadashi, Minota, Seiji, Takahashi, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/21 13/51 13/95 38 42 42/44 631/443/592/75 692/4019/592 Aneurysm Aneurysms Animal models Bone marrow Cardiovascular diseases CD11b antigen Colony-stimulating factor Coronary artery Coronary artery disease Cytokines Fibrosis Granulocyte-macrophage colony-stimulating factor Heart diseases Humanities and Social Sciences Inflammation Interleukin 10 Interleukin 6 Intravenous administration Kawasaki disease Lethality Mucocutaneous lymph node syndrome multidisciplinary Phosphorylation Science Science (multidisciplinary) Supplements Syk protein Tumor necrosis factor-TNF Tumor necrosis factor-α Vasculitis
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